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2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) Chithunzi Chowonetsedwa
  • 2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) 1

2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0)

Chemical Property:

Molecular Formula C5H4Cl2N2
Molar Misa 163
Kuchulukana 1.39 g/mL pa 25 °C (kuyatsa)
Melting Point 26-28 °C (kuyatsa)
Boling Point 108-109 °C/11 mmHg (kuyatsa)
Pophulikira >230°F
Kusungunuka Kusungunuka mu chloroform, ether, ethyl acetate ndi toluene
Kuthamanga kwa Vapor 0.079mmHg pa 25°C
Maonekedwe ufa kuti mtanda uchotse madzi
Mtundu Zoyera kapena Zopanda Mtundu mpaka Zoyera kapena Zopanda mtundu
pKa -2.44±0.29(Zonenedweratu)
Mkhalidwe Wosungira Mpweya wozizira, 2-8 ° C

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Ngozi ndi Chitetezo

Zizindikiro Zowopsa C - Zowononga
Zizindikiro Zowopsa 34 - Zimayambitsa kuwotcha
Kufotokozera Zachitetezo S26 - Mukakhudza maso, yambani nthawi yomweyo ndi madzi ambiri ndikupempha uphungu wachipatala.
S36/37/39 - Valani zovala zodzitchinjiriza zoyenera, magolovesi ndi chitetezo chamaso / kumaso.
S45 - Pakachitika ngozi kapena ngati simukumva bwino, funsani upangiri wachipatala nthawi yomweyo (onetsani chizindikirocho ngati kuli kotheka.)
S27 - Chotsani nthawi yomweyo zovala zonse zowonongeka.
Ma ID a UN UN 3261 8/PG 2
WGK Germany 3
TSCA Inde
HS kodi 29335990
Kalasi Yowopsa 8
Packing Group III

2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) Zambiri

Gwiritsani ntchito 2, 4-dichloro-5-methylpyrimidine angagwiritsidwe ntchito pokonza 2-fluoro-5-trifluoromethylpyrimidine. 2-fluoro-5-trifluoromethylpyrimidine ndi yofunika yapakatikati pa kaphatikizidwe mankhwala, amene angagwiritsidwe ntchito popanga wosakanikirana mphete dihydrofuran mankhwala, ndi wosakaniza mphete dihydrofuran mankhwala angagwiritsidwe ntchito monga G mapuloteni cholandirira GPR119 modulators, pochiza matenda a shuga, kunenepa kwambiri komanso matenda a dyslipidemia. Komanso, 2-fluoro-5-trifluoromethylpyrimidine Angagwiritsidwenso ntchito ngati wapakatikati mu synthesis mankhwala zochizira matenda a Alzheimer ndi schizophrenia.
kukonzekera 5-methyluracil 75g(0.59mol), phosphorous oxychloride 236g, triethylamine hydrochloride 16.5g(0.12mol), anawonjezera ku botolo anachita, kutenthedwa ndi 100 ℃ ~ 110 ℃, Reflux anachita 5H, utakhazikika ℃ phosphorous chloride, 4 ℃ chloride chloride, utakhazikika ndi chloride. 248 (1.19mol), kusungirako kutentha 2H. Atamaliza kuchitapo kanthu, phosphorous oxychloride inapezedwanso ndi distillation pansi pa kupanikizika kochepa, ndipo distillation pansi pa kupanikizika kocheperako inapitilizidwa kupeza 88g (0.54mol) ya 2, 4-dichloro-5-methylpyrimidine mu zokolola za 91.5%.
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