2 4-Difluorobenzoic acid (CAS # 1583-58-0)

Kugwiritsa ntchito

2, 4-difluorobenzoic asidi ndi yofunika mankhwala ndi mankhwala wapakatikati, monga 2, 4-difluorobenzoic asidi zimagwiritsa ntchito synthesize antifungal mankhwala fluconazole, voriconazole ndi mankhwala mankhwala wapakatikati 4-fluorosalicylic acid, mankhwala wapakatikati 3, 5-difluoro, etc. 2, 4-difluorobenzoic acid akhoza Angagwiritsidwenso ntchito pazinthu zamadzimadzi za kristalo, zomwe zili ndi ubwino wamtengo wapatali komanso mwayi wabwino wamsika.

Kukonzekera

Onjezani 2, 4-dinitrotoluene ndi madzi ku chotengera chotengera, sinthani pH kukhala 7, yambitsani ndikutentha mpaka 75 ° C. Potaziyamu permanganate, magnesium sulphate ndi chothandizira kusintha magawo adawonjezeredwa m'magulu. Pambuyo powonjezera, pitirizani kuyambitsa ndikuchitapo kanthu pa kutentha kosasintha kwa maola atatu. Sefa ikatentha ndikutsuka keke ya fyuluta ndi madzi otentha. Gwirizanitsani zosefera, acidify ndi 35% hydrochloric acid kuti pH 2-3, pali ambiri precipitates woyera pambuyo makhiristo kwathunthu precipitated, wosefedwa, kutsukidwa, recrystallized, ndi zouma kupeza makhiristo woyera monga 2,4-dinitrobenzoic acid. . Chiŵerengero cha 2, 4-dinitrotoluene ndi potaziyamu permanganate ndi 2.4:1. Zokolola zamtunduwu ndi 90.7%.

onjezerani N, N-dimethylmethylphthalamide mu chidebe chomwe chimachitikira, kutentha mpaka 100 ~ 110 ℃, preheat kwa 0.5 ~ 1h. Onjezani zouma za anhydrous potaziyamu fluoride poyambitsa ndikusunga kutentha kwa preheated kwa 0.5-1h. Pambuyo pake, 2, 4-dinitrobenzoic acid ndi hexyltrimethylammonium bromide adawonjezedwa mwachangu ku chotengeracho nthawi imodzi, ndipo kutentha kunapitilizidwa mpaka 120 ℃, kutentha kunasungidwa ndipo kusunthaku kunapitilira. Pambuyo pa maola 7 a reflux, zosungunulira zimabwezeretsedwanso ndi distillation, ndiyeno madziwo amathiridwa ndi nthunzi. Gawo losonkhanitsidwa ndi emulsion yoyera. Pambuyo pa kuyima kwa nthawi, kachigawo kakang'ono kamene kamene kamakhudzidwa ndi mafuta kamatsika pansi, madzi oyera oyera pamwamba amatsanuliridwa, ndipo mafuta amakhazikika kuti apangitse makhiristo oyera kuti apeze zinthu zopanda pake; zinthu zopanda pake zimasinthidwanso, kusefera kwa Suction, kutsuka, ndi kuyanika kuti mupeze makhiristo oyera a 2,4-difluorobenzoic acid. Chiyerekezo cha kuchuluka kwa 2, 4-dinitrobenzoic acid ndi potaziyamu fluoride ndi 2.7: 1. Zokolola zamtunduwu ndi 72.4%.

Mawu Oyamba
2,4-Difluorobenzoic acid ndi organic pawiri. Zotsatirazi ndizofotokozera za katundu, ntchito, njira zokonzekera ndi chitetezo cha 2,4-difluorobenzoic acid:

Ubwino:
- Maonekedwe: 2,4-Difluorobenzoic asidi ndi woyera crystalline olimba.
- Kusungunuka: Imasungunuka muzosungunulira wamba monga ethanol, methanol ndi methylene chloride.

Gwiritsani ntchito:
- Zida zowonera: Itha kugwiritsidwanso ntchito ngati imodzi mwazinthu zopangira zopangira zopangira zowoneka bwino komanso makanema owoneka bwino.
- Ntchito zamafakitale: 2,4-difluorobenzoic acid ingagwiritsidwe ntchito pamakampani opanga zamagetsi, zokutira ndi mapulasitiki okhala ndi anti-corrosion, anti-oxidation ndi anti-ultraviolet zotsatira.

Njira:
- 2,4-Difluorobenzoic acid imatha kupezeka ndi fluorination ya hydrofluoric acid ndi p-methylanisole.

Zambiri Zachitetezo:
- Pogwira ntchito, fumbi liyenera kupewedwa kuti musapumedwe ndi kukhudzana ndi maso. Nthawi yomweyo, mpweya wabwino uyenera kusungidwa.
- Pewani kukhudzana ndi ma oxidizing amphamvu kapena ma asidi amphamvu kuti mupewe zoopsa