2-Amino-3-bromo-5-(trifluoromethyl)-pyridine (CAS# 79456-30-7)

Mawu Oyamba

2-Amino-3-brom-5-(trifluoromethyl)pyridine ndi organic pawiri ndi mankhwala chilinganizo C6H4BrF3N2. Mapangidwe ake a maselo ali ndi mphete ya pyridine ndi atomu ya bromine, komanso gulu la amino ndi gulu la trifluoromethyl.

Maonekedwe ake akuthupi ndi awa:

Maonekedwe: Cholimba choyera

Malo osungunuka: 82-84 ° C

Malo otentha: 238-240 ° C

Kachulukidwe: 1.86g/cm³

Kusungunuka: Kusungunuka pang'ono m'madzi, kusungunuka mu zosungunulira organic monga ethanol, etha ndi dichloromethane.

Chimodzi mwazofunikira kwambiri za 2-Amino-3-bromo-5-(trifluoromethyl) pyridine ndi monga mankhwala apakatikati. Angagwiritsidwe ntchito pokonzekera biologically yogwira mankhwala, monga mankhwala, mankhwala ndi utoto. Kuphatikiza apo, itha kugwiritsidwanso ntchito ngati ligand kutenga nawo gawo pamachitidwe amankhwala omwe amapangidwa ndi ayoni achitsulo, monga zitsulo zopangidwa ndi zitsulo komanso kuzindikira kwamankhwala.

The synthesis njira pawiri chingapezeke ndi bromopyridine ndi amination anachita. Masitepe enieni akuphatikizapo kuchitapo kanthu kwa bromopyridine ndi ammonia, m'malo mwa atomu ya bromine ndi gulu la amino pansi pa zofunikira, ndikuyambitsa gulu la trifluoromethyl pansi pa zochita za trifluoromethylation reagent.

Ponena za chitetezo, 2-Amino-3-bromo-5-(trifluoromethyl)pyridine ndi organic pawiri ndipo ayenera kugwiritsidwa ntchito mosamala njira zoteteza. Zitha kukhala zowononga komanso zowononga maso, khungu ndi kupuma. Pewani kukhudzana mwachindunji pakugwira ntchito ndikuonetsetsa kuti mpweya wabwino ukuyenda bwino. Ndikoyenera kuvala zida zodzitetezera monga magalasi odzitetezera, magolovesi ndi masks oteteza mukamagwiritsa ntchito. Panthawi yotaya, chonde tsatirani zofunikira zakutaya zinyalala za mankhwala. Pakusungirako, ziyenera kusungidwa pamalo otsika kutentha, owuma ndi mpweya wabwino, kupewa kukhudzana ndi okosijeni ndi zidulo.