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2-Amino-6-bromopyridine (CAS# 19798-81-3) Chithunzi chojambulidwa
  • 2-Amino-6-bromopyridine (CAS# 19798-81-3) 1

2-Amino-6-bromopyridine (CAS# 19798-81-3)

Chemical Property:

Molecular Formula C5H5BrN2
Molar Misa 173.01
Kuchulukana 1.710±0.06 g/cm3(Zonenedweratu)
Melting Point 88-91 °C (kuyatsa)
Boling Point 273.0±20.0 °C(Zonenedweratu)
Pophulikira 118.9°C
Kusungunuka kwamadzi Zosungunuka pang'ono m'madzi.
Kusungunuka Chloroform (Pang'ono), Methanol (Pang'ono Kwambiri)
Kuthamanga kwa Vapor 0.0059mmHg pa 25°C
Maonekedwe ufa woyera mpaka bulauni
Mtundu Wachikasu pang'ono mpaka bulauni
pKa 2.73±0.24 (Zonenedweratu)
Mkhalidwe Wosungira Sungani pamalo amdima, Osindikizidwa owuma, Kutentha kwachipinda

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Ngozi ndi Chitetezo

Zizindikiro Zowopsa R36/37/38 - Zokwiyitsa maso, kupuma komanso khungu.
R20/21/22 - Zowopsa pokoka mpweya, kukhudzana ndi khungu komanso kumeza.
Kufotokozera Zachitetezo S26 - Mukakhudza maso, yambani nthawi yomweyo ndi madzi ambiri ndikupempha uphungu wachipatala.
S36 - Valani zovala zoyenera zodzitetezera.
S36/37/39 - Valani zovala zodzitchinjiriza zoyenera, magolovesi ndi chitetezo chamaso / kumaso.
WGK Germany 3
HS kodi 29333999
Kalasi Yowopsa ZOKWIYA

 

 

2-Amino-6-bromopyridine (CAS# 19798-81-3) Zambiri

Mwachidule 2-amino m'malo nayitrogeni munali asanu ndi membala heterocyclic mankhwala ndi zofunika ntchito mu makampani mankhwala, monga 2-amino -6-Bromopyridine ndi chimodzi mwa zinthu zofunika mu kupanga mankhwala ndi ulimi mankhwala mamolekyu, ndipo chimagwiritsidwa ntchito mu synthesis. za zinthu zachilengedwe, mankhwala, zounikira ndi mankhwala osiyanasiyana abwino.
Kugwiritsa ntchito 2-amino m'malo nayitrogeni munali asanu membed heterocyclic mankhwala ndi zofunika ntchito mu makampani mankhwala, monga 2-amino -6-Bromopyridine ndi chimodzi mwa zinthu zofunika mu kupanga mankhwala ndi ulimi mankhwala mamolekyu, ndipo chimagwiritsidwa ntchito mu synthesis. za zinthu zachilengedwe, mankhwala, zounikira ndi mankhwala osiyanasiyana abwino.
Kukonzekera Kukonzekera kwa 2-amino-6-bromopyridine: Add 2-fluoro-6-bromo-pyridine (1mmol), pentamidine hydrochloride (2mmol), sodium tert-butoxide (3mmol), HO (0.5mL) ndi diethylene glycol dimethyl ether (2.5) ml) mu chubu cha 25 ml reaction. Zomwezo zidachitika pa 150 ℃ kwa maola 24. Zochitazo zitatha, zidakhazikika mpaka kutentha. Onjezani 10mL ya ethyl acetate kuti muzimitse zomwe zikuchitika, onjezerani 6mL wa madzi amchere odzaza kuti musambe, kulekanitsa gawo la organic, kenaka chotsani gawo lamadzi ndi ethyl acetate kwa nthawi 3 (mlingo wa ethyl acetate nthawi iliyonse ndi 6mL) ndikuphatikiza organic. Gawo, kuwonjezera anhydrous sodium sulfate kuti ziume, kuchotsa zosungunulira kuphatikizapo organic zosungunulira ndi inorganic zosungunulira ndi vacuum distillation, ndiyeno kulekanitsa zosungunulira organic ndi mzati chromatography kupeza chandamale mankhwala 2-amino-6-bromopyridine ndi zokolola za 93%.
ntchito mankhwala apakatikati.
kwa kaphatikizidwe koyenera kwa 7-azafindole mumphika umodzi; za kaphatikizidwe wa mankhwala odana ndi HIV

 

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