2-Chloro-3-fluoro-6-picoline (CAS# 374633-32-6)

Mawu Oyamba

Mawonekedwe: Nthawi zambiri imakhala yopanda utoto mpaka yachikasu yopepuka, mawonekedwe ake amatanthauza kuti amatha kumva kuwala ndi kutentha, ndipo m'pofunika kuchitapo kanthu kuti mupewe kuwongolera kutentha ndi kutentha panthawi yosungira komanso yoyendetsa, monga kugwiritsa ntchito mabotolo agalasi a bulauni ndikusunga. m'nyumba yosungiramo zinthu zoziziritsa kukhosi kuti mtundu usachuluke komanso kuwonongeka.

Kusungunula: Pawiri ali ndi solubility wabwino mu zosungunulira wamba organic, monga toluene ndi dichloromethane, amatsatira mfundo ya solubility ofanana, ndipo ali kugwirizana ndi zosungunulira organic chifukwa cha gawo hydrophobic wa molekyulu; Komabe, kusungunuka m'madzi kumakhala kochepa, ndipo mgwirizano wamphamvu wa haidrojeni pakati pa mamolekyu amadzi ndizovuta kusweka bwino ndi molekyulu, zomwe zimapangitsa kuti zikhale zovuta kuwabalalitsa.
Kuwiritsa ndi kachulukidwe: Deta ya mfundo yowira imagwirizana kwambiri ndi kusakhazikika kwake ndipo imatha kupereka magawo ofunikira pamachitidwe monga distillation ndi kuyeretsa, koma mwatsoka mtengo wake wowiritsa sunawululidwe. Kachulukidwe ake ndi okwera pang'ono kuposa madzi, ndipo kumvetsetsa kachulukidwe kungathandize kuyerekeza molondola kuchuluka kwa kutembenuka kwa voliyumu muzoyeserera kapena njira zamafakitale monga kusamutsa madzi ndi metering yolondola.
Mankhwala katundu
M'malo mwake: Atomu ya chlorine ndi atomu ya fluorine mu molekyulu ndi malo omwe angathe kuchitapo kanthu. Mu nucleophilic substitution reaction, ma nucleophiles amphamvu amatha kumenyana ndi malo omwe ma atomu a chlorine ndi fluorine ali, m'malo mwa maatomu ofanana, ndikupanga zatsopano za pyridine. Mwachitsanzo, zakhala zikuphatikizidwa ndi ma nucleophile okhala ndi nayitrogeni komanso sulfure kuti apange ma heterocyclic angapo okhala ndi nayitrogeni okhala ndi zida zovuta kwambiri zopezera mankhwala kapena kaphatikizidwe kazinthu.
Redox reaction: mphete ya pyridine yokha imakhala yosasunthika, koma pamene zowonjezera zowonjezera, monga potaziyamu permanganate ndi hydrogen peroxide zimaphatikizidwa ndi zinthu za acidic, makutidwe ndi okosijeni amatha kuchitika, zomwe zimapangitsa kuwonongeka kapena kusinthidwa kwa pyridine mphete; Mosiyana ndi zimenezi, ndi oyenera kuchepetsa wothandizira, monga zitsulo hydrides, ndi theoretically zotheka kuti hydrogenation wa intramolecular unsaturated nsinga.
Chachinayi, njira ya kaphatikizidwe
Njira yodziwika bwino ndikuyambira kuchokera kuzinthu zosavuta za pyridine ndikumanga pang'onopang'ono chandamale kudzera mumayendedwe a halogenation ndi fluorination. Mankhwala oyambira a pyridine amayamba kusankha methylated ndipo magulu a methyl amayambitsidwa nthawi yomweyo; Ndiye ntchito halogenation reagents, monga klorini ndi madzi klorini, ndi catalysts abwino ndi zinthu anachita, kukwaniritsa kumayambiriro maatomu chlorine; Pomaliza, ma reagents opangidwa ndi fluorinated, monga Selectfluor, adagwiritsidwa ntchito kuwunikira molondola malo omwe akupita kuti apeze 2-chloro-3-fluoro-6-methylpyridine.
Ntchito
Mankhwala kaphatikizidwe intermediates: wapadera kapangidwe ake amakondedwa ndi mankhwala mankhwala, ndipo ndi apamwamba wapakatikati chitukuko latsopano antibacterial, sapha mavairasi oyambitsa, ndi antitumor mankhwala. Zamagetsi zamagetsi ndi mawonekedwe a malo a mphete za pyridine ndi zolowa m'malo mwake zimatha kumangirira mwachindunji mapuloteni mu vivo, ndipo akuyembekezeka kusinthidwa kukhala zosakaniza zogwira ntchito bwino kwambiri pambuyo posintha masitepe angapo.
Sayansi yazinthu: M'munda wa kaphatikizidwe kazinthu zachilengedwe, itha kugwiritsidwa ntchito popanga zida zogwirira ntchito za polima, zida za fulorosenti, ndi zina, chifukwa cha kuthekera kwake kudziwitsa bwino chlorine, maatomu a fluorine ndi mapangidwe a pyridine, zida zopangira zida zapadera zamagetsi ndi kuwala. katundu, ndikulimbikitsa chitukuko cha zamakono zamakono monga zipangizo zanzeru ndi zipangizo zowonetsera.