5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7)
Ngozi ndi Chitetezo
| Zizindikiro Zowopsa | R22 - Zowopsa ngati zitamezedwa R37/38 - Zokwiyitsa dongosolo la kupuma ndi khungu. R41 - Kuopsa kwa kuwonongeka kwakukulu kwa maso R36/37/38 - Zokwiyitsa maso, kupuma komanso khungu. R20 - Zowopsa pokoka mpweya |
| Kufotokozera Zachitetezo | S26 - Mukakhudza maso, yambani nthawi yomweyo ndi madzi ambiri ndikupempha uphungu wachipatala. S36/37/39 - Valani zovala zodzitchinjiriza zoyenera, magolovesi ndi chitetezo chamaso / kumaso. S36 - Valani zovala zoyenera zodzitetezera. |
| Ma ID a UN | 2811 |
| WGK Germany | 3 |
| HS kodi | 29337900 |
| Zowopsa | Zovulaza |
| Kalasi Yowopsa | ZOKWIYA |
Zambiri Zolozera
| Gwiritsani ntchito | 5-bromo-2-hydroxy-3-nitropyridine ndi organic wapakatikati kuti angagwiritsidwe ntchito pokonza mankhwala 3-amino-1-(2-oxo-2-(3 '-(trifluoromethyl)--[1,1'-biphenyl ]-4-yl) ethyl) -5-(pyrrole alkyl-1-yl-sulfonyl) pyridin-2 (1H)-one, pawiri iyi ndi DOCK1 inhibitory compound. |
| kaphatikizidwe njira | asidi nitric (60-61%,3.5mL) anawonjezera kuti yankho (10mL) wa 5-bromopyridine -2(1H) -imodzi (1.75g,10.1mmol) mu asidi sulfuric pa 0 ℃. The osakaniza amaloledwa kutenthedwa ndi firiji ndi analimbikitsa kwa 3 hours. Zomwe osakaniza zimatsanuliridwa mu madzi oundana ndipo zotsatira zake zimasonkhanitsidwa ndi kusefera. The chifukwa mankhwala anasambitsidwa ndi madzi ndi zouma mu vakuyumu, kupereka 5-bromo-2-hydroxy-3-nitropyridine (960mg, 43% zokolola) monga woyera olimba. 1H NMR(500MHz,CDCl3)δ:8.57(s,1H),8.26(s,1H). |
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