5-Fluorocytosine (CAS# 2022-85-7)
Ngozi ndi Chitetezo
| Zizindikiro Zowopsa | R40 - Umboni wochepa wa zotsatira za carcinogenic R36/37/38 - Zokwiyitsa maso, kupuma komanso khungu. R63 - Chiwopsezo chotheka kuvulaza mwana wosabadwa |
| Kufotokozera Zachitetezo | S22 - Osapumira fumbi. S24/25 - Pewani kukhudzana ndi khungu ndi maso. S45 - Pakachitika ngozi kapena ngati simukumva bwino, funsani upangiri wachipatala nthawi yomweyo (onetsani chizindikirocho ngati kuli kotheka.) S36/37 - Valani zovala zoyenera zodzitchinjiriza ndi magolovesi. S36/37/39 - Valani zovala zodzitchinjiriza zoyenera, magolovesi ndi chitetezo chamaso / kumaso. S27 - Chotsani nthawi yomweyo zovala zonse zowonongeka. S26 - Mukakhudza maso, yambani nthawi yomweyo ndi madzi ambiri ndikupempha uphungu wachipatala. |
| WGK Germany | 2 |
| Mtengo wa RTECS | HA6040000 |
| FLUKA BRAND F CODES | 10-23 |
| HS kodi | 29335990 |
| Zowopsa | Poizoni/Kuwala Kumva Kuwala |
| Kalasi Yowopsa | IRRITANT, KUPANDA KUKHALA |
| Poizoni | LD50 mu mbewa (mg/kg):>2000 pakamwa ndi sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine (CAS# 2022-85-7) Chiyambi
khalidwe
Izi ndi zoyera kapena zoyera za crystalline ufa, zopanda fungo kapena zonunkhira pang'ono. Kusungunuka pang'ono m'madzi, kusungunuka kwa 1.2% pa 20 °C m'madzi, kusungunuka pang'ono mu Mowa; Ndi pafupifupi osasungunuka mu chloroform ndi ether; Kusungunuka mu dilute hydrochloric acid kapena kuchepetsa sodium hydroxide solution. Ndiwokhazikika kutentha kwa firiji, imatulutsa makhiristo pakazizira, ndipo gawo laling'ono limasinthidwa kukhala 5-fluorouracil likatenthedwa.
Izi ndi mankhwala antifungal apanga mu 1957 ndipo ntchito mchitidwe kuchipatala mu 1969, ndi zoonekeratu antibacterial zotsatira pa Candida, cryptococcus, mitundu bowa ndi Aspergillus, ndipo palibe chopinga kwambiri bowa ena.
Kulepheretsa kwake pa bowa ndi chifukwa cholowa m'maselo a bowa tcheru, pomwe pansi pa zochita za nucleopyine deaminase, amachotsa magulu amino kuti apange antimetabolite-5-fluorouracil. Zotsirizirazi zimasinthidwa kukhala 5-fluorouracil deoxynucleoside ndipo zimalepheretsa thymine nucleoside synthetase, zimatchinga kutembenuka kwa uracil deoxynucleoside kukhala thymine nucleoside, ndipo zimakhudza kaphatikizidwe ka DNA.
ntchito
Antifungal. Amagwiritsidwa ntchito makamaka mucocutaneous candidiasis, candidal endocarditis, candidiasis nyamakazi, cryptococcal meningitis ndi chromomycosis.
Kugwiritsa ntchito ndi mlingo M'kamwa, 4 ~ 6g tsiku, ogaŵikana 4 nthawi.
chitetezo
Kuwerengera kwa magazi kuyenera kuyang'aniridwa nthawi zonse panthawi ya utsogoleri. Odwala ndi chiwindi ndi impso insufficiency ndi magazi matenda ndi amayi apakati ayenera kugwiritsa ntchito mosamala; Contraindicated odwala kwambiri aimpso insufficiency.
Shading, yosungirako mpweya.
