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5-Fluorouracil (CAS# 51-21-8) Chithunzi Chowonetsedwa
  • 5-Fluorouracil (CAS# 51-21-8) 1

5-Fluorouracil (CAS# 51-21-8)

Chemical Property:

Molecular Formula C4H3FN2O2
Molar Misa 130.08
Kuchulukana 1.4593 (chiyerekezo)
Melting Point 282-286 °C (dec.) (kuyatsa)
Boling Point 190-200°C/0.1mmHg
Kusungunuka kwamadzi 12.2 g/L 20 ºC
Kusungunuka Kusungunuka pang'ono mu ethanol. Ndi pafupifupi insoluble mu chloroform ndi kusungunuka mu sodium hydroxide solution.
Maonekedwe White kapena woyera ngati crystalline ufa
Mtundu woyera
Merck 14,4181
Mtengo wa BRN 127172
pKa pKa 8.0±0.1 (H2O) (Zosatsimikizika);3.0±0.1(H2O) (Zosatsimikizika)
PH 4.3-5.3 (10g/l, H2O, 20℃)
Mkhalidwe Wosungira 2-8 ° C
Kukhazikika Wokhazikika. Kuwala kosavuta. Zoyaka. Zosagwirizana ndi oxidizing amphamvu, maziko amphamvu.
Zomverera Zosamva mpweya
Refractive Index 1.542
MDL Chithunzi cha MFCD00006018
Zakuthupi ndi Zamankhwala malo osungunuka 282-286°C (dec.)(lit.) Sungani pa 0-5
solubility H2O: 10 mg/mL, momveka

mawonekedwe a ufa

mtundu woyera

kusungunuka kwa madzi 12.2g/L 20 oC
Mpweya Womva
Mtengo wa 14,4181
Mtengo wa 127172
Gwiritsani ntchito Kwa khansa ya m'mimba, khansa ya mutu ndi khosi, khansa ya amayi, khansa ya m'mapapo, khansa ya chiwindi, khansa ya chikhodzodzo ndi chithandizo cha khansa yapakhungu.

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Zizindikiro Zowopsa R22 - Zowopsa ngati zitamezedwa
R20/21/22 - Zowopsa pokoka mpweya, kukhudzana ndi khungu komanso kumeza.
R52 - Zowononga zamoyo zam'madzi
R25 - Poizoni ngati atamezedwa
Kufotokozera Zachitetezo S36 - Valani zovala zoyenera zodzitetezera.
S36/37 - Valani zovala zoyenera zodzitchinjiriza ndi magolovesi.
S36/37/39 - Valani zovala zodzitchinjiriza zoyenera, magolovesi ndi chitetezo chamaso / kumaso.
S22 - Osapumira fumbi.
S45 - Pakachitika ngozi kapena ngati simukumva bwino, funsani upangiri wachipatala nthawi yomweyo (onetsani chizindikirocho ngati kuli kotheka.)
S26 - Mukakhudza maso, yambani nthawi yomweyo ndi madzi ambiri ndikupempha uphungu wachipatala.
Ma ID a UN UN 2811 6.1/PG 3
WGK Germany 3
Mtengo wa RTECS YR0350000
FLUKA BRAND F CODES 10-23
TSCA T
HS kodi 29335995
Zowopsa Zokwiyitsa/Zowopsa Kwambiri
Kalasi Yowopsa 6.1
Packing Group III
Poizoni LD50 pakamwa pa Kalulu: 230 mg/kg

 

Mawu Oyamba

Izi zimasinthidwa koyamba kukhala 5-fluoro-2-deoxyuracil nucleotides m'thupi, zomwe zimalepheretsa thymine nucleotide synthase ndikuletsa kutembenuka kwa deoxyuracil nucleotides kukhala deoxythymine nucleotides, potero kuletsa DNA biosynthesis. Kuphatikiza apo, poletsa kuphatikizika kwa uracil ndi rotic acid mu RNA, zotsatira za kuletsa kaphatikizidwe ka RNA zimatheka. Izi ndi mankhwala ozungulira ma cell, makamaka omwe amalepheretsa ma cell a S.

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