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alpha-Arbutin (CAS# 84380-01-8) Chithunzi Chowonetsedwa
  • alpha-Arbutin (CAS# 84380-01-8) 1

alpha-Arbutin (CAS# 84380-01-8)

Chemical Property:

Molecular Formula C12H16O7
Misa ya Molar 272.25
Kuchulukana 1.556±0.06 g/cm3(Zonenedweratu)
Melting Point 195-196 ° C
Boling Point 561.6±50.0 °C(Zonenedweratu)
Pophulikira 293.4°C
Kusungunuka Kusungunuka mu methanol, Mowa, DMSO ndi zina zosungunulira organic
Kuthamanga kwa Vapor 1.9E-13mmHg pa 25°C
Maonekedwe White crystalline ufa
Mtundu White mpaka Off-White
Mtengo wa BRN 89675
pKa 10.10±0.15(Zonenedweratu)
Mkhalidwe Wosungira 2-8 ° C
Refractive Index 1.65
MDL Mtengo wa MFCD09838262
Zakuthupi ndi Zamankhwala Malo osungunuka 195-196 ° C

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Ngozi ndi Chitetezo

WGK Germany 3

 

Zambiri

Mwachidule arbutin ndi hydroquinone glycoside pawiri, mankhwala dzina 4-hydroxyphenyl-d-glucopyranoside (y), alipo mu zimbalangondo zipatso, bilberry ndi zomera zina, ndi latsopano sanali irriter, sanali matupi awo sagwirizana, zachilengedwe whitening yogwira zinthu ndi zogwirizana kwambiri. Arbutin ali ndi magulu awiri apangidwe komanso ogwira ntchito m'maselo ake: imodzi ndi yotsalira ya shuga; Zina ndi gulu la phenolic hydroxyl. Thupi la α-arbutin limawoneka ngati ufa wonyezimira wonyezimira, womwe umasungunuka kwambiri m'madzi ndi ethanol.
mphamvu α-arbutin imakhala ndi chithandizo chabwino kwambiri pazipsera zomwe zimayambitsidwa ndi UV Burns, zimakhala ndi anti-inflammatory, kukonza ndi kuyera. Ikhoza kulepheretsa kupanga ndi kuyika kwa melanin, kuchotsa mawanga ndi mawanga.
njira yochitira Njira yoyera ya α-arbutin imalepheretsa mwachindunji ntchito ya tyrosinase, potero imachepetsa kupanga melanin, m'malo mochepetsa kupanga melanin poletsa kukula kwa maselo kapena mawonekedwe amtundu wa tyrosinase. Popeza α-Arbutin ndi yogwira ntchito bwino komanso yotetezeka yoyera, makampani ambiri odzikongoletsera kunyumba ndi kunja atengera α-arbutin m'malo mwa β-arbutin ngati chowonjezera choyera.
Kugwiritsa ntchito alpha-Arbutin ndi mankhwala omwe ali ofanana ndi arbutin, amatha kuletsa kupanga ndi kuyika kwa melanin, kuchotsa mawanga ndi mawanga. Zotsatira zikuwonetsa kuti arbutin imatha kuletsa ntchito ya tyrosinase pamlingo wocheperako, ndipo zoletsa zake pa tyrosinase ndizabwino kuposa za arbutin. alpha-arbutin angagwiritsidwe ntchito ngati whitening wothandizira mu zodzoladzola.
kuyeretsedwa ndi chizindikiritso chitsanzo chomwe chinapezedwa ndi zomwe zimachitika poyamba chinatulutsidwa ndi ethyl acetate, kenaka chinachotsedwa ndi n-butanol, zitsanzozo zinasonkhanitsidwa ndi evaporation pa evaporator yozungulira ndi centrifuged. Wopambana adawunikidwa ndi HPLC ndikufaniziridwa ndi HPLC chromatogram ya α-arbutin, ngati zitsanzo ndi α-arbutin zili ndi nthawi yosungira yofananira zikuyerekezedwa, komanso ngati chitsanzocho chili ndi α-Arbutin chimangoganiziridwa.

Chogulitsacho chitatha kuchotsedwa ndi kuyeretsedwa chinadziwika ndi njira yabwino ya ion ya LC-ESI-MS/MS. Poyerekeza kuchuluka kwa mamolekyulu a α-bear fruit ndi kuchuluka kwa molekyulu ya α-arbutin, zitha kudziwa ngati mankhwalawo ndi α-arbutin.
Kugwiritsa ntchito α-arbutin imatha kuletsa ntchito ya tyrosinase pamalo otsika kwambiri, zoletsa zake pa tyrosinase ndizabwinoko kuposa za arbutin.
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