N-(tert-Butoxycarbonyl)-L-aspartic acid (CAS# 13726-67-5)
Ngozi ndi Chitetezo
| Zizindikiro Zowopsa | Xn - Zowopsa |
| Zizindikiro Zowopsa | R20/21/22 - Zowopsa pokoka mpweya, kukhudzana ndi khungu komanso kumeza. R36/37/38 - Zokwiyitsa maso, kupuma komanso khungu. |
| Kufotokozera Zachitetezo | S26 - Mukakhudza maso, yambani nthawi yomweyo ndi madzi ambiri ndikupempha uphungu wachipatala. S36 - Valani zovala zoyenera zodzitetezera. S24/25 - Pewani kukhudzana ndi khungu ndi maso. |
| WGK Germany | 3 |
| HS kodi | 2924 19 00 |
N-(tert-Butoxycarbonyl)-L-aspartic acid (CAS# 13726-67-5) Chiyambi
Boc-L-aspartic acid ndi organic pawiri ntchito ngati gulu kuteteza peptide synthesis. Njira yake yamakina ndi C13H19NO6 ndipo kulemera kwake ndi 293.29. Boc imayimira N-tert-butoxycarbonyl.
Boc-L-aspartic acid makamaka imakhala ndi zotsatirazi:
1. Maonekedwe: ufa wa crystalline wopanda mtundu;
2. malo osungunuka: pafupifupi 152-155 ℃;
3. Kusungunuka: Kusungunuka mu zosungunulira zina za organic, monga dimethyl sulfoxide ndi dichloromethane, zosasungunuka m'madzi;
4. bata: kuwonongeka kungachitike ngati pali okosijeni wamphamvu ndi kuwala.
Kugwiritsa ntchito kwakukulu kwa Boc-L-aspartic acid ndi gulu loteteza mu kaphatikizidwe ka peptide. Imateteza gulu la amine kumbali ya L-aspartic acid kuti iteteze zomwe sizingachitike. Panthawi ya kaphatikizidwe ka peptide, Boc-L-aspartic acid imakumana ndi ma amino acid ena kapena magawo a peptide kupanga unyolo watsopano wa peptide. Mukamaliza kaphatikizidwe, gulu loteteza litha kuchotsedwa ndi chithandizo cha asidi kuti mupeze peptide kapena mapuloteni omwe mukufuna.
Boc-L-aspartic acid nthawi zambiri imakonzedwa ndi njira zodziwika zopangira. Mwachidule, L-aspartic acid imatha kupangidwa pochita L-aspartic acid ndi t-Boc-L acid ndi dimethylformamide. Njira zenizeni zopangira zitha kupezeka m'mabuku ofunikira amankhwala.
Ponena za chitetezo, muyenera kulabadira mfundo zotsatirazi:
1. Boc-L-aspartic acid ndi mankhwala omwe ali ndi poizoni wina. Njira zodzitetezera zoyenera ziyenera kuchitidwa panthawi ya ntchito, monga kuvala magolovesi, magalasi ndi zovala za labotale;
2. pewani kutulutsa ufa kapena njira yothetsera, pewani kukhudzana ndi khungu ndi maso;
3. Mukamagwiritsa ntchito ndikugwiritsa ntchito Boc-L-aspartic acid, iyenera kusindikizidwa ndikusungidwa kuti isakhudzidwe ndi okosijeni ndi kuwala kwamphamvu;
4. Pochita ndi zinyalala za Boc-L-aspartic acid, ziyenera kutayidwa motsatira malamulo amderalo.
Boc-L-aspartic acid makamaka imakhala ndi zotsatirazi:
1. Maonekedwe: ufa wa crystalline wopanda mtundu;
2. malo osungunuka: pafupifupi 152-155 ℃;
3. Kusungunuka: Kusungunuka mu zosungunulira zina za organic, monga dimethyl sulfoxide ndi dichloromethane, zosasungunuka m'madzi;
4. bata: kuwonongeka kungachitike ngati pali okosijeni wamphamvu ndi kuwala.
Kugwiritsa ntchito kwakukulu kwa Boc-L-aspartic acid ndi gulu loteteza mu kaphatikizidwe ka peptide. Imateteza gulu la amine kumbali ya L-aspartic acid kuti iteteze zomwe sizingachitike. Panthawi ya kaphatikizidwe ka peptide, Boc-L-aspartic acid imakumana ndi ma amino acid ena kapena magawo a peptide kupanga unyolo watsopano wa peptide. Mukamaliza kaphatikizidwe, gulu loteteza litha kuchotsedwa ndi chithandizo cha asidi kuti mupeze peptide kapena mapuloteni omwe mukufuna.
Boc-L-aspartic acid nthawi zambiri imakonzedwa ndi njira zodziwika zopangira. Mwachidule, L-aspartic acid imatha kupangidwa pochita L-aspartic acid ndi t-Boc-L acid ndi dimethylformamide. Njira zenizeni zopangira zitha kupezeka m'mabuku ofunikira amankhwala.
Ponena za chitetezo, muyenera kulabadira mfundo zotsatirazi:
1. Boc-L-aspartic acid ndi mankhwala omwe ali ndi poizoni wina. Njira zodzitetezera zoyenera ziyenera kuchitidwa panthawi ya ntchito, monga kuvala magolovesi, magalasi ndi zovala za labotale;
2. pewani kutulutsa ufa kapena njira yothetsera, pewani kukhudzana ndi khungu ndi maso;
3. Mukamagwiritsa ntchito ndikugwiritsa ntchito Boc-L-aspartic acid, iyenera kusindikizidwa ndikusungidwa kuti isakhudzidwe ndi okosijeni ndi kuwala kwamphamvu;
4. Pochita ndi zinyalala za Boc-L-aspartic acid, ziyenera kutayidwa motsatira malamulo amderalo.
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