Boc-L-Glutamic acid 1-benzyl ester (CAS # 30924-93-7)

Mawu Oyamba

Boc-L-Glutamic acid 1-benzyl ester (Boc-L-Glutamic acid 1-benzyl ester) ndi organic pawiri ndi mankhwala formula wa C17H19NO6 ndi wachibale molecular mass 337.34. Ndi cholimba choyera, chosungunuka mu zosungunulira za organic monga ethanol, dimethylformamide ndi chloroform.

Boc-L-Glutamic acid 1-benzyl ester imagwiritsidwa ntchito popanga ma peptide. Ikhoza kugwiritsidwa ntchito ngati micellar wothandizira kapena gulu loteteza kuteteza gulu la amino acid kuti liteteze zotsatira zosafunikira muzochitika za mankhwala, ndipo panthawi imodzimodziyo zimatha kusintha zokolola. Kuphatikiza apo, itha kugwiritsidwanso ntchito popanga mankhwala a polypeptide ndi mamolekyu okhudzana ndi bioactive.

Njira yokonzekera Boc-L-Glutamic acid 1-benzyl ester nthawi zambiri ndikuyambitsa gulu loteteza la Boc mu gulu la amino la glutamic acid, ndikuchita esterification ndi benzyl anhydride ester pamalo awa. Zomwe zimachitika nthawi zambiri zimachitika pansi pa ndale kapena zofunikira ndipo nthawi zambiri zimafunikira nthawi kuti zitsimikizire kuti zomwe zachitikazo zimakwaniritsidwa. Chogulitsidwacho chikhoza kuyeretsedwa ndi crystallization kapena njira zina zoyeretsera.

Pazambiri zachitetezo, chitetezo chenicheni cha Boc-L-Glutamic acid 1-benzyl ester chimafunikira kafukufuku ndi kuunika kwina. Komabe, monga mankhwala, imatha kukhala ndi mkwiyo komanso poizoni. Njira zoyenera za labotale ziyenera kutsatiridwa pokhudzana kapena kugwiritsidwa ntchito, ndipo njira zodzitetezera ziyenera kutsatiridwa, kuphatikiza kuvala zida zodzitetezera (monga G., magolovesi a labu, magalasi a labu, ndi zina). Pogwiritsidwa ntchito kapena kutaya, zinyalala ziyenera kutayidwa moyenera kuti zipewe kuwononga chilengedwe.