Boc-L-Tyrosine methyl ester (CAS # 4326-36-7)

Mawu Oyamba

N-Boc-L-Tyrosine Methyl Ester ndi mankhwala omwe dzina lawo ndi N-tert-butoxycarbonyl-L-tyrosine methyl ester. Makhalidwe ake ndi awa:

1. Maonekedwe: oyera mpaka imvi crystalline olimba;

5. Kusungunuka: kusungunuka mu zosungunulira za organic monga ethanol ndi dimethylformamide (DMF), zosasungunuka m'madzi.

N-Boc-L-tyrosine methyl ester amagwiritsidwa ntchito kwambiri mu kaphatikizidwe organic kuteteza amino zidulo mu synthesis wa mankhwala polypeptide. Amagwiritsidwa ntchito ngati gulu loteteza la L-tyrosine kuti ateteze zomwe sizichitika mwachindunji zomwe zingachitike. Zomwezo zikatha, gulu loteteza likhoza kuchotsedwa pansi pamikhalidwe yoyenera kuti lipeze chinthu choyenera chandamale.

Njira yokonzekera N-Boc-L-tyrosine methyl ester nthawi zambiri imakhala ndi izi:

1. Sungunulani L-tyrosine mu dimethylformamide (DMF);

2. Onjezani sodium carbonate kuti muchepetse gulu la carboxyl la tyrosine;

3. Methanol ndi methyl carbonate (MeOCOCl) amawonjezedwa pazomwe zimapangidwira kuti apange N-Boc-L-tyrosine methyl ester. Zomwe zimachitika nthawi zambiri zimatenthedwa, ndipo methyl carbonate yochulukirapo imagwiritsidwa ntchito kuwonetsetsa kuti zomwe zimachitikazo zimapitilira.

N-Boc-L-tyrosine methyl ester ndiyokhazikika, koma ikufunikabe kuchitidwa mosamala. Zotsatirazi ndi zambiri zokhudza chitetezo:

1. Pewani kukhudzana ndi khungu ndi maso: Magolovesi otetezera oyenera ayenera kuvala kuti asakhudzidwe mwachindunji ndi gulu;

2. Pewani kupuma movutikira: mpweya wabwino uyenera kutsimikizika pamalo ogwirira ntchito kuti asapumedwe ndi mpweya wambiri;

3. Kusungirako: Iyenera kusungidwa pamalo ozizira, ouma ndi kupewa kukhudzana ndi mpweya, asidi amphamvu, kapena maziko amphamvu.

Ponseponse, N-Boc-L-tyrosine methyl ester ndi yofunika kwambiri pakati pa kaphatikizidwe ka organic ndipo imakhala ndi gawo lofunikira pakuphatikizika kwa mankhwala a peptide. Chisamaliro chiyenera kutengedwa kuti chigwiritsidwe ntchito moyenera mukamagwiritsa ntchito komanso pogwira.