Boc-N-beta-Trityl-L-asparagine (CAS# 132388-68-2)

Kufotokozera Zachitetezo	S22 - Osapumira fumbi. S24/25 - Pewani kukhudzana ndi khungu ndi maso.
WGK Germany	3
HS kodi	2924 29 70
Kalasi Yowopsa	ZOKWIYA

NAA-tert-butoxycarbonyl N Γ-trityl aspartamide ndi organic compound, yomwe nthawi zambiri imatchulidwa ndi chidule cha Boc-Phe-OtBu. Ili ndi fomula C30H37NO4 ndipo ndi yoyera yolimba.Chilengedwe:
Boc-Phe-OtBu ndi hydrophobic ndipo sasungunuka m'madzi, koma amasungunuka mosavuta mu zosungunulira za organic monga methanol, ethanol ndi dichloromethane. Imakhala yokhazikika pakuwala komanso kutentha.

Gwiritsani ntchito:
Boc-Phe-OtBu amagwiritsidwa ntchito makamaka poteteza magulu komanso oyambira omwe amakhudzidwa ndi kaphatikizidwe ka organic. Mu kaphatikizidwe, angagwiritsidwe ntchito kuteteza onunkhira amino zidulo, mu synthesis wa polypeptides ndi mapuloteni, kuteteza magulu yogwira kuteteza zimachitika mbali zimachitikira. Kuphatikiza apo, itha kugwiritsidwanso ntchito pokonzekera mankhwala ena, monga mankhwala, utoto ndi zinthu zachilengedwe.

Njira Yokonzekera:
Kukonzekera kwa Boc-Phe-OtBu kumatheka chifukwa cha mankhwala. Njira imodzi yodziwika bwino ndikuyankhira p-benzoic acid ndi t-butyl hydroxyformate kupanga p-tert-butoxycarbonyl benzoate. Ndiye anachita ndi triphenylamine kupereka chomaliza mankhwala Boc-Phe-OtBu.

Zambiri Zachitetezo:
Boc-Phe-OtBu ndi yotetezeka ngati ikugwiritsidwa ntchito bwino. Komabe, monga mankhwala, imafunikabe kusungidwa ndi kusamaliridwa bwino. Pewani kukhudzana ndi okosijeni wamphamvu, kupewa kupuma fumbi komanso kupewa kukhudzana ndi khungu. Mukamagwiritsa ntchito, valani zida zoyenera zodzitetezera, monga magolovesi ndi magalasi odzitetezera. Mukakumana mwangozi kapena kumeza, funsani upangiri wachipatala mwachangu ndikudziwitsa dokotala za mankhwalawo. Malamulo ndi malamulo a chitetezo m'deralo ayenera kutsatiridwa pogwira ndi kutaya zinyalala.