Cbz-L-Glutamic acid 1-benzyl ester (CAS # 3705-42-8)
Mawu Oyamba
Z-Glu-OBzl(Z-Glu-OBzl) ndi gulu lachilengedwe lomwe limagwiritsidwa ntchito ngati gulu loteteza ma amino acid. Zotsatirazi ndizofotokozera za katundu, ntchito, kukonzekera ndi chitetezo cha pawiri:
Chilengedwe:
-Chilinganizo cha maselo: C17H17NO4
-Kulemera kwa maselo: 303.32g / mol
-Maonekedwe: ufa woyera wa crystalline
- Malo osungunuka: 84-85 ° C
-Kusungunuka: Kusungunuka mu zosungunulira za organic monga dimethyl sulfoxide ndi dimethylformamide
- Gulu loteteza la Cbz litha kuchotsedwa ndi chothandizira palladium hydride pansi pa acidic
Gwiritsani ntchito:
- Z-Glu-OBzl ndi gulu loteteza la glutamic acid (Glu), lomwe lingagwiritsidwe ntchito popanga zotumphukira za amino acid, ma polypeptides ndi mapuloteni.
-Monga gulu loteteza ma amino acid muzinthu zopangira organic, zimatha kuteteza gulu la amine la glutamic acid, kuteteza kuti lisakhudzidwe ndi machitidwe osakhala enieni, ndikuthandizira kuchotsa pakafunika.
Njira Yokonzekera:
-Kukonzekera kwa Z-Glu-OBzl nthawi zambiri kumaphatikizapo njira zambirimbiri ndipo kumaphatikizapo machitidwe angapo a mankhwala. Imodzi mwa njira zodziwika bwino ndikuteteza gulu la carboxyl la glutamic acid monga t-butoxycarbonyl ester (Boc) ndikuteteza gulu la amino ngati Cbz. Pomaliza, chinthu chomwe mukufuna Z-Glu-OBzl chimapangidwa ndikuchita ndi benzyl chloroformate.
Zambiri Zachitetezo:
- Z-Glu-OBzl iyenera kuchitidwa ngati mankhwala osokoneza bongo komanso kupewa kukhudzana mwachindunji ndi khungu ndi maso.
-Pogwiritsidwa ntchito mu labotale, njira zotetezera ziyenera kutsatiridwa, kuphatikizapo kuvala magalasi otetezera, magolovesi ndi malaya a labotale.
-Kukoka mpweya kapena kuyamwa pawiri kuyenera kupewedwa ndipo njira zopewera moto ndi kuphulika ziyenera kuchitidwa posungira.
-Chigawochi chiyenera kuyikidwa pamalo abwino mpweya wabwino panthawi yokonza, ndipo zinyalala ziyenera kutayidwa moyenera malinga ndi malamulo a m'deralo.
