Dodec-11-yn-1-ol (CAS# 18202-10-3)

Chemical Property:

Molecular Formula	C12H22O
Molar Misa	182.3
Kuchulukana	0.8530 (chiyerekezo)
Melting Point	18.8°C (chiyerekezo)
Boling Point	285.73 ° C (kuyerekeza molakwika)
pKa	15.20±0.10 (Zonenedweratu)
Mkhalidwe Wosungira	2-8 ° C
Refractive Index	1.4535 (chiyerekezo)

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Dodec-11-yn-1-ol (CAS# 18202-10-3) Zambiri

kukonzekera

NaH (7.5g, 60% kubalalitsidwa kwamafuta, 326mmol) idawonjezedwa mtanda ndi mtanda ku dodecyl -3-alkyne -1-mowa (10.0g,54.95mmol; GF Smith) mu olimbikitsa 0 ℃ njira ya ethylenediamine (40mL). Pambuyo pa 1h, kutentha kumakwezedwa mpaka 70 ℃. Pambuyo 8h ina, kuziziritsa anachita osakaniza ku 0 ° C, mosamala kuthetsa ndi madzi oundana-ozizira (100mL), ndi kuchotsa ndi ether (3 × 60mL). The kuphatikiza ether Tingafinye anatsukidwa ndi madzi (100mL). Kusamba kwamadzi kunachotsedwanso ndi ether (3 × 60mL). Zosakaniza zophatikizika za organic zidakhazikika pansi pa vacuum, ndipo zotsalirazo zidasinthidwa ndi chromatography pogwiritsa ntchito 10% EtOAc/hexane kuti apeze 11-dodecyne -1-alcohol (7.4g,74%) yokhala ndi 3-5% ya ma isomers ena amchigawo ( regioisomer). TLC:30% EtOAc/hexane, Rf ≈ 0.4;1H NMR(300MHz,CDCl3)δ3.66(t,2H,J = 7.3Hz), 2.14-2.21(m,2H),1.93(t,J = 1.9Hz), ,1H),1.20-1.63(m,16H).

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