Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate（CAS# 503615-07-4 )

Mawu Oyamba

Zotsatirazi ndizofotokozera za katundu, ntchito, njira zokonzekera ndi chidziwitso cha chitetezo cha apixaban intermediate 3:

Ubwino:

Apixaban intermediate 3 ndi organic pawiri. Ndiwolimba komanso kusungunuka mu zosungunulira organic monga ether ndi ethyl acetate.

Ntchito: Nthawi zambiri amagwiritsidwa ntchito popanga opaleshoni komanso kuchiza ululu waukulu.

Njira:

Njira yokonzekera ya apixaban yapakati 3 ikhoza kuchitidwa ndi masitepe otsatirawa: p-nitrobenzoic acid imachitidwa ndi hypobutylthiourea pamaso pa acetic acid ndi thionyl chloride kupeza N-(p-nitrophenyl) -N-(hypobutylthioyllurea) formic acid, ndiyeno, anachita ndi sodium hydroxide mu sodium okusayidi ndi methanol njira kupeza apixaban wapakatikati 3.

Chidziwitso cha Chitetezo: Njira zoyendetsera chitetezo ziyenera kutsatiridwa mukamagwiritsa ntchito ndikugwiritsa ntchito mankhwalawa. Kulumikizana mwachindunji kapena kupumira mpweya kumatha kuvulaza kwambiri thanzi la munthu. Zambiri zachitetezo chake ziyenera kuwunikiridwa ndikukonzedwa motsatira malamulo ndi malangizo ofunikira kuti zitsimikizire kuti zikugwiritsidwa ntchito motetezeka. Poyesa kaphatikizidwe ka mankhwala, ziyenera kugwiritsidwa ntchito m'malo oyenerera a labotale ndipo zida zodzitetezera monga magalasi amagetsi, magolovesi oteteza, ndi zovala zodzitchinjiriza ziyenera kugwiritsidwa ntchito.