Fmoc-L-glutamic acid-gamma-benzyl ester (CAS# 123639-61-2)
Fluorene methoxycarbonyl-L-glutamic acid-Γ-benzyl ndi organic pawiri ntchito peptide kaphatikizidwe mu olimba-gawo kaphatikizidwe. Chikhalidwe chake:
- Maonekedwe: Choyera mpaka chachikasu cholimba
- Kusungunuka: Fmoc-L-Glu(OtBu) -OH ili ndi kusungunuka kwabwino pakati pa zosungunulira wamba.
Kugwiritsa ntchito kwakukulu kwa Fmoc-L-Glu (OtBu) -OH ndi gulu loteteza mu kaphatikizidwe ka peptide. Popanga unyolo wa peptide, Fmoc-L-Glu(OtBu)-OH imamangiriza ku ma amino acid, kuteteza zochita zawo kuti zisakhudzidwe mwanjira ina ndi zina. Zomwezo zitatha, Fmoc-L-Glu(OtBu) -OH ikhoza kuchotsedwa pochotsa gulu loteteza kuti libwezeretse ntchito ya amino acid.
Kukonzekera kwa Fmoc-L-Glu(OtBu)-OH ndizovuta kwambiri ndipo nthawi zambiri kumafuna kugwiritsa ntchito njira zingapo zopangira organic. Glutamic acid imayendetsedwa ndi bromoacetate kuti ipeze ethyl glutamate. Kenako, ethyl glutamate imayendetsedwa ndi mowa wa benzyl kupanga ethyl glutamate benzyl alcohol ester. Ethyl glutamate benzyl alcohol ester idachitidwa ndi Fmoc-Cl kuti ipange chandamale cha Fmoc-L-Glu(OtBu)-OH.
Chidziwitso cha Chitetezo: Fmoc-L-Glu(OtBu)-OH ndi mankhwala a mu labotale ndipo amayenera kugwiritsidwa ntchito pansi pa ma labotale otetezeka. Tsatirani njira zodzitetezera ku labotale, kuphatikiza kuvala zida zodzitetezera (monga magulovu a labu, magalasi, ndi zina zotero), kupewa kukhudzana ndi khungu ndi pokoka mpweya, komanso kugwira ntchito mu labotale yolowera mpweya wabwino. Chosakanizacho chiyenera kusungidwa mu chidebe chopanda mpweya, kutali ndi kuyatsa ndi okosijeni.
