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Fmoc-O-tert-butyl-L-tyrosine (CAS# 71989-38-3) Chithunzi Chowonetsedwa
  • Fmoc-O-tert-butyl-L-tyrosine (CAS# 71989-38-3) 1

Fmoc-O-tert-butyl-L-tyrosine (CAS# 71989-38-3)

Chemical Property:

Molecular Formula C28H29NO5
Misa ya Molar 459.53
Kuchulukana 1.218±0.06 g/cm3(Zonenedweratu)
Melting Point ~150°C (Dec.)
Boling Point 658.2±55.0 °C(Zonenedweratu)
Kuzungulira Kwapadera (α) -28 º (c=1, DMF)
Pophulikira 351.9°C
Kusungunuka Chloroform (Pang'ono), DMF (Pang'ono), Methanol (Pang'ono)
Kuthamanga kwa Vapor 3.2E-18mmHg pa 25°C
Maonekedwe Mwala woyera
Mtundu Choyera
Mtengo wa BRN 4216652
pKa 2.97±0.10 (Zonenedweratu)
Mkhalidwe Wosungira Sungani pansi +30 ° C.
Refractive Index -30 ° (C=1, DMF)
MDL Mtengo wa MFCD00037129
Zakuthupi ndi Zamankhwala White crystalline ufa; Insoluble m'madzi ndi petroleum ether, sungunuka mu ethyl acetate, methanol ndi DMF;mp ndi 150-151 ℃; Kuzungulira kwapadera kwa kuwala [α]20D 10 5.2 °(0.5-2.0 mg/ml, ethyl acetate),[α]20D-27.6 °(0.5-2.0 mg/ml,DMF),[α]20D-6 °(0.5- 2.0 mg/ml, methanol).

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Zizindikiro Zowopsa Xi - Zosangalatsa
Zizindikiro Zowopsa 36/37/38 - Zokwiyitsa maso, kupuma komanso khungu.
Kufotokozera Zachitetezo S26 - Mukakhudza maso, yambani nthawi yomweyo ndi madzi ambiri ndikupempha uphungu wachipatala.
S24/25 - Pewani kukhudzana ndi khungu ndi maso.
WGK Germany 3
HS kodi 2924 29 70

 

Mawu Oyamba

Fluorene methoxycarbonyl-oxotert-butyl-tyrosine ndi mankhwala omwe nthawi zambiri amafupikitsidwa ngati FMOC-Tyr(tBu)-OH. Zotsatirazi ndizofotokozera za chikhalidwe chake, kugwiritsa ntchito, kukonzekera ndi chitetezo:

 

Ubwino:

- Maonekedwe: Choyera kapena choyera cholimba.

- Kusungunuka: Kusungunuka mu zosungunulira za organic, monga dimethyl sulfoxide ndi dimethylformamide.

 

Gwiritsani ntchito:

- Kuteteza magulu mu kaphatikizidwe ka mankhwala: Magulu a FMOC angagwiritsidwe ntchito kuteteza magulu a amino mu mankhwala a phenolic kuti asachite. FMOC-Tyr(tBu) -OH itha kugwiritsidwa ntchito ngati poyambira pokonzekera unyolo wa peptide mu kaphatikizidwe ka mankhwala.

 

Njira:

Njira yokonzekera FMOC-Tyr(tBu)-OH ikhoza kukwaniritsidwa ndi izi:

- Fluorenyl chloride (FMOC-Cl) imapangidwa ndi tert-butyl (tBu-NH2) kuti ipereke fluorenylmethoxycarbonyl-tert-butichsyl (FMOC-tBu-NH-).

- Kenako, yankhani zotsatira za FMOC-tBu-NH- ndi tyrosine (Tyr-OH) kuti apange FMOC-Tyr(tBu)-OH.

 

Zambiri Zachitetezo:

- Kugwiritsa ntchito FMOC-Tyr (tBu)-OH kumayenera kutsatiridwa ndi ma protocol a labotale.

- Pewani kukhudza khungu ndi maso, ndipo valani magolovesi oteteza ndi magalasi mukamagwiritsa ntchito.

- Gwiritsani ntchito pamalo olowera mpweya wabwino, kutali ndi moto ndi zoyaka.

- Siyenera kutulutsidwa mu chilengedwe ndipo iyenera kugwiridwa ndikutayidwa motsatira malamulo akumaloko.

 

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