L-Pyroglutamic acid CAS 98-79-3
Ngozi ndi Chitetezo
| Zizindikiro Zowopsa | Xi - Zosangalatsa |
| Zizindikiro Zowopsa | 36/37/38 - Zokwiyitsa maso, kupuma komanso khungu. |
| Kufotokozera Zachitetezo | S26 - Mukakhudza maso, yambani nthawi yomweyo ndi madzi ambiri ndikupempha uphungu wachipatala. S36 - Valani zovala zoyenera zodzitetezera. S37/39 - Valani magolovesi oyenera komanso chitetezo chamaso / kumaso |
| WGK Germany | 3 |
| Mtengo wa RTECS | TW3710000 |
| FLUKA BRAND F CODES | 21 |
| TSCA | Inde |
| HS kodi | 29337900 |
| Mawu Oyamba | pyroglutamic acid ndi 5-oxyproline. Amapangidwa ndi kutaya madzi m'thupi pakati pa gulu la α-NH2 ndi γ-hydroxyl gulu la glutamic acid kuti apange mgwirizano wa molecular lactam; Itha kupangidwanso potaya gulu la Amido mu molekyulu ya glutamine. Ngati glutathione synthetase akusowa, kungayambitse pyroglutamemia, mndandanda wa matenda zizindikiro. Pyroglutamemia ndi vuto la organic acid metabolism chifukwa cha kuchepa kwa glutathione synthetase. chipatala mawonetseredwe kubadwa 12-24 hours isanayambike, pang`onopang`ono hemolysis, jaundice, aakulu kagayidwe kachakudya Acidosis, maganizo matenda, etc.; Mkodzo uli ndi pyroglutamic acid, lactic acid, Alpha deoxy4 glycoloacetic acid lipid. Chithandizo, symptomatic, kulabadira kusintha zakudya pambuyo pa zaka. |
| katundu | L-pyroglutamic acid, yomwe imadziwikanso kuti L-pyroglutamic acid, L-pyroglutamic acid. Kuchokera ku ethanol ndi petroleum etha osakaniza mu mpweya wa colorless orthorhombic pawiri chulucho Crystal, malo osungunuka a 162 ~ 163 ℃. Zosungunuka m'madzi, mowa, acetone ndi acetic acid, ethyl acetate-sungunuka, osasungunuka mu ether. Kuzungulira kwapadera kwa kuwala -11.9 °(c = 2,H2O). |
| Features ndi ntchito | khungu la munthu lili ndi ntchito yonyowa ya zinthu zosungunuka m'madzi-zosungunuka zachilengedwe, zomwe zimapangidwira pafupifupi amino acid (muli 40%), pyroglutamic acid (yokhala ndi 12%), mchere wa inorganic (Na, K, Ca, Mg, ndi zina). okhala ndi 18.5%), ndi zinthu zina zakuthupi (zokhala ndi 29.5%). Choncho, pyroglutamic acid ndi chimodzi mwa zigawo zikuluzikulu za khungu moisturizing factor, ndipo moisturizing mphamvu yake kuposa glycerol ndi propylene glycol. Ndipo zopanda poizoni, zopanda kukondoweza, ndi Khungu lamakono, Zodzoladzola Zosamalira Tsitsi zabwino kwambiri zopangira. Pyroglutamic acid imalepheretsanso ntchito ya tyrosine oxidase, potero imalepheretsa kuyika kwa zinthu za "melanoid" pakhungu, zomwe zimapangitsa khungu kukhala loyera. Ali ndi kufewetsa pakhungu, angagwiritsidwe ntchito zodzoladzola msomali. Kuphatikiza pa kugwiritsa ntchito zodzoladzola, L-pyroglutamic acid imathanso kutulutsa zotumphukira ndi zinthu zina za organic, zomwe zimakhala ndi zotsatira zapadera pazantchito zapamtunda, zowonekera komanso zowala, etc. Itha kugwiritsidwanso ntchito ngati surfactant ya detergents; Chemical reagents kwa chigamulo cha racemic amines; Organic intermediates. |
| njira yokonzekera | L-pyroglutamic acid imapangidwa pochotsa mphindi imodzi ya madzi kuchokera ku molekyulu ya L-glutamic acid, ndipo njira yake yokonzekera ndiyosavuta, masitepe ofunikira ndikuwongolera kutentha ndi nthawi yothira madzi. (1) 500g ya L-glutamic acid inawonjezeredwa ku beaker 100 ml, ndipo beaker inatenthedwa ndi mafuta osamba, ndipo kutentha kunakwezedwa mpaka 145 mpaka 150 ° C., ndi kutentha kunasungidwa kwa mphindi 45 chifukwa cha kuchepa madzi m'thupi. anachita. Njira yothetsera madzi m'thupi inali Tan. (2) Pambuyo pomaliza kutulutsa madzi m'thupi, yankho linatsanuliridwa m'madzi otentha ndi voliyumu pafupifupi 350, ndipo yankho linasungunuka kwathunthu m'madzi. Pambuyo pozizira mpaka 40 mpaka 50 ° C., kuchuluka koyenera kwa carbon activated kudawonjezedwa kuti asinthe mtundu (kubwerezedwa kawiri). Njira yopanda mtundu yowonekera idapezedwa. (3) pamene colorless mandala njira anakonza sitepe (2) mwachindunji usavutike mtima ndi chamunthuyo kuchepetsa voliyumu pafupifupi theka, kutembenukira kwa osamba madzi ndi kupitiriza kuganizira buku la pafupifupi 1/3, mukhoza kusiya Kutentha, ndi mu osamba madzi otentha kuchepetsa crystallization, 10 kwa 20 hours pambuyo pokonzekera colorless prismatic makhiristo. Kuchuluka kwa L-pyroglutamic acid mu zodzoladzola kumatengera kapangidwe kake. Izi angagwiritsidwe ntchito pa zodzoladzola mu mawonekedwe a 50% anaikira njira. |
| glutamic acid | glutamic acid ndi amino acid omwe amapanga mapuloteni, ali ndi unyolo wa ionized acidic mbali, ndipo amawonetsa hydrotropism. Glutamic acid imatha kupangidwa ndi cyclization kukhala pyrrolidone carboxylic acid, i.e., pyroglutamic acid. glutamic acid imakhala yochuluka kwambiri m'mapuloteni onse a phala, omwe amapereka alpha-ketoglutarate kupyolera mu tricarboxylic acid cycle. Alpha ketoglutaric acid ikhoza kupangidwa mwachindunji kuchokera ku ammonia pansi pa catalysis ya glutamate dehydrogenase ndi NADPH (coenzyme II), komanso ikhoza kuthandizidwa ndi aspartate aminotransferase kapena alanine aminotransferase, glutamic acid imapangidwa ndi transamination ya aspartic acid kapena alanine; Kuphatikiza apo, glutamic acid imatha kusinthidwa mosinthika ndi proline ndi ornithine (kuchokera ku arginine), motsatana. Chifukwa chake glutamate ndi amino acid osafunikira kwenikweni. Pamene asidi glutamic deaminated pansi catalysis wa glutamate dehydrogenase ndi NAD (coenzyme I) kapena anasamutsidwa kuchokera amino gulu pansi catalysis wa aspartate aminotransferase kapena alanine aminotransferase kupanga alpha ketoglutarate, amalowa tricarboxylic asidi mkombero ndi kupanga shuga kudzera mu gluconeogenic pathway, kotero glutamic acid ndi yofunika glycogenic amino acid. glutamic acid mu minofu yosiyanasiyana (monga minofu, chiwindi, ubongo, ndi zina zotero) imatha kupanga glutamine ndi NH3 kupyolera mu catalysis ya glutamine synthetase, ndi detoxification mankhwala a ammonia, makamaka mu ubongo minofu, komanso kusunga ndi kugwiritsa ntchito mawonekedwe a ammonia m'thupi (onani "glutamine ndi metabolism yake"). glutamic acid imapangidwa ndi acetyl-CoA monga cofactor ya mitochondrial carbamoyl phosphate synthase (yomwe imakhudzidwa ndi kaphatikizidwe ka urea) kudzera mu catalysis ya acetyl-glutamate synthase. γ-aminobutyric acid (GABA) imapangidwa kuchokera ku decarboxylation ya glutamic acid, makamaka yochulukirachulukira mu minofu yaubongo, komanso imawoneka m'magazi, ntchito yake yokhudzana ndi thupi imawonedwa ngati inhibitory neurotransmitter, antispasmodic ndi hypnotic zotsatira zochitidwa ndi kulowetsedwa kwachipatala kwa echinocandin kungapezeke kudzera mu GABA. The catabolism ya GABA imalowa mu tricarboxylic acid cycle potembenuza GABA transaminase ndi aldehyde dehydrogenase kukhala succinic acid kupanga GABA shunt. |
| Gwiritsani ntchito | amagwiritsidwa ntchito ngati zapakati mu kaphatikizidwe organic, zowonjezera chakudya, etc. amagwiritsidwa ntchito muzakudya, mankhwala, zodzoladzola ndi mafakitale ena |
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