Methyl 2-cyanoisonicotinate (CAS # 94413-64-6)
Ngozi ndi Chitetezo
| Kalasi Yowopsa | 6.1 |
Njira yopangira
pawiri chandamale anakonzedwa ndi makutidwe ndi okosijeni, amidation ndi kutaya madzi m'thupi ndi methyl 2-methyl 4-pyridinecarboxylate (2) monga zoyambira. kapangidwe kake kanatsimikiziridwa ndi 1H NMR ndi MS, ndipo zokolola zonse zinali 53.0%. Zotsatira za chiŵerengero cha chakudya, kutentha kwa crystallization, nthawi yochitira zinthu ndi zina zomwe zimagwiritsidwa ntchito pa mankhwalawa zinaphunziridwa ndi kuyesa kwa chinthu chimodzi, ndipo ndondomekoyi inakonzedwa bwino: n (2): n (potassium permanganate) = 1.0: 2.5, kutentha kwa crystallization 0 ~5 ℃;n (methyl 2-carboxyl -4-pyridinecarboxylate):n (sulfoxide) = 1.0:1.4, zochita; Kutaya madzi m'thupi kumasankha dongosolo la trifluoroacetic anhydride-triethylamine monga dehydrating agent. Njirayi ndi yosavuta kugwiritsa ntchito, momwe zinthu zimachitikira ndizofatsa, zosavuta kukulitsa kupanga, ndipo zimakhala ndi phindu lothandizira.
Gwiritsani ntchito
Tobisostat amagwiritsidwa ntchito pochiza hyperuricemia ya gout. Poyerekeza ndi mankhwala achikhalidwe allopurinol (purine analog), sizingakhudze purine ndi pyridine metabolism ndi enzyme ntchito, ndipo imachepetsa uric acid Zotsatira zake zimakhala zamphamvu, palibe mlingo waukulu wobwerezabwereza umafunika, ndipo chitetezo ndi chabwino. Methyl 2-cyano-4-pyridine carboxylate ndi chinthu chofunikira kwambiri popanga Tobiso.
