Mitotan (CAS # 53-19-0)

Chemical Property:

Molecular Formula	C14H10Cl4
Molar Misa	320.04
Kuchulukana	1.3118 (kuyerekeza movutikira)
Melting Point	77-78°C(kuyatsa)
Boling Point	405.59°C (kuyerekeza molakwika)
Kusungunuka kwamadzi	<0.1 g/100 mL pa 24 ºC
Kusungunuka	DMSO: soluble20mg/mL, zomveka
Maonekedwe	ufa
Mtundu	woyera mpaka beige
Merck	13,6237 / 13,6237
Mtengo wa BRN	2056007
Mkhalidwe Wosungira	M'mlengalenga, Kutentha kwa Zipinda
Refractive Index	1.6000 (chiyerekezo)
Zakuthupi ndi Zamankhwala	Malo osungunuka 76-78 ° C madzi osungunuka <0.1g/100 mL pa 24°C
Gwiritsani ntchito	Izi ndi zofufuza zasayansi zokha ndipo sizigwiritsidwa ntchito pazinthu zina.
Maphunziro a in vitro	Mu mzere wa cell wa mbewa wa TalphaT1, Mitotane imalepheretsa kufotokoza ndi kutulutsa kwa TSH, kutsekereza kuyankha kwa TSH ku TRH, ndikuchepetsa mphamvu ya cell, ndikupangitsa apoptosis. M'maselo a pituitary TSH-secreting mouse, Mitotane samasokoneza mahomoni a chithokomiro, koma amachepetsa mwachindunji ntchito yachinsinsi komanso mphamvu ya selo. Mitotane imapangitsa adrenal cortical necrosis, kuwonongeka kwa nembanemba ya mitochondrial, komanso kumangirira kosasinthika ku mapuloteni a CYP. Mitotane (10-40 μm) inaletsa kutsekemera kwa basal ndi cAMP-induced cortisol koma sizinapangitse kufa kwa selo. Mitotane inasonyeza zotsatira zolepheretsa pa basal Star ndi P450scc mapuloteni. Mitotane (40 μm) inachepetsa kwambiri milingo ya mRNA ya Star, CYP11A1 ndi cyp21. Mitotane (40 μm) inatsala pang'ono kuthetsa kulowetsedwa kwa STAR, CYP11A1, CYP17, ndi CYP21 mRNA ndi adenosine 8-bromo-cyclic phosphate. Mu gawo la S la maselo a H295R, kuphatikiza kwa Mitotane ndi gemcitabine kunawonetsa kusagwirizana ndi kusokoneza gemcitabine-mediated inhibition mu selo.
Kuphunzira mu vivo	Mu makoswe, Mitotane (60 mg / kg) inachepetsa kwambiri adrenal mitochondrial ndi microsomal "P-450" ndi mapuloteni a microsomal ndi 34%,55% ndi 35%.

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Zizindikiro Zowopsa	Xn - Zowopsa
Zizindikiro Zowopsa	40 - Umboni wochepa wa zotsatira za carcinogenic
Kufotokozera Zachitetezo	36/37 - Valani zovala zoteteza ndi magolovesi oyenera.
Ma ID a UN	3249
WGK Germany	3
Mtengo wa RTECS	KH7880000
HS kodi	2903990002
Kalasi Yowopsa	6.1(b)
Packing Group	III

Mawu Oyamba

Mitotane ndi mankhwala okhala ndi dzina la N,N'-methylene diphenylamine. Zotsatirazi ndizofotokozera za katundu, ntchito, njira zokonzekera ndi chidziwitso cha chitetezo cha mitotane:

Ubwino:

- Mitotane ndi cholimba cha crystalline chopanda mtundu chomwe chimasungunuka mu zosungunulira za organic monga ethanol, ether, ndi chloroform.

- Mitotane ili ndi fungo lamphamvu.

Gwiritsani ntchito:

- Mitotane imagwiritsidwa ntchito makamaka pophatikiza machitidwe mu organic synthesis ndipo imagwiritsidwa ntchito ngati reagent komanso chothandizira.

- Itha kutenga nawo mbali pamachitidwe osiyanasiyana amankhwala, monga kuphatikiza ma alkynes, alkylation yamafuta onunkhira, ndi zina.

Njira:

- Mitotane ikhoza kupangidwa ndi njira ziwiri. Formaldehyde imakhudzidwa ndi diphenylamine pansi pamikhalidwe yamchere kupanga N-formaldehyde diphenylamine. Kenako, ndi pyrolysis kapena controlled oxidation reaction, imasinthidwa kukhala mitotane.

Zambiri Zachitetezo:

- Mitotane ndi mankhwala osokoneza bongo ndipo sayenera kukhudzana mwachindunji ndi khungu ndi maso. Zida zodzitetezera zoyenera monga magolovesi, magalasi, ndi zovala zodzitetezera ziyenera kuvalidwa pogwira ntchito.

- Posunga ndikugwira, samalani kuti mutseke ndikuteteza ku kuwala kuti musagwirizane ndi mpweya ndi chinyezi.

- Mitotane imawola pa kutentha kwambiri kuti ipange mpweya wapoizoni, kupewa kutentha kapena kukhudzana ndi zinthu zina zoyaka moto.

- Onani malamulo akumaloko ndikutsata njira zoyendetsera chitetezo powataya.

Zam'mbuyo: 4-(4-methoxyphenyl) -1-butanol (CAS# 52244-70-9)

Ena: 2-Chloro-5-aminopyridine (CAS# 5350-93-6)

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