N-Boc-N'-tosyl-D-histidine (CAS# 69541-68-0)

Mawu Oyamba

Boc-D-His(Tos)-OH(Boc-D-His(Tos)-OH) ndi mankhwala omwe ali ndi zotsatirazi:

Chilengedwe:

1. Maonekedwe: oyera olimba

2. chilinganizo cha maselo: C21H25N3O6S

3. kulemera kwa maselo: 443.51

4. Malo osungunuka: pafupifupi 110-115°C

Gwiritsani ntchito:

Boc-D-His(Tos) -OH amagwiritsidwa ntchito popanga organic synthesis ngati gulu loteteza D-histidine (D-His). Ntchito zake zazikulu ndi izi:

1. Mu kaphatikizidwe ka polypeptide, imagwiritsidwa ntchito popanga ma polypeptide omwe ali ndi gulu loteteza D-histidine.

2. Ntchito ngati wapakatikati m'munda wa mankhwala umagwirira kwa synthesis wa biologically yogwira chandamale mankhwala.

3. Kupanga ndi kaphatikizidwe ka mankhwala opangira mankhwala mu kafukufuku.

Njira Yokonzekera:

Kukonzekera kwa Boc-D-His(Tos)-OH nthawi zambiri kumachitika ndi izi:

1. D-histidine (D-His) adachitidwa ndi p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) kuti apereke D-histidine p-toluenesulfonyl (D-His-Tos).

2. Pansi pa zinthu zamchere, D-His-Tos imayendetsedwa ndi n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) kuti ipange Boc-D-His(Tos)-OH.

Zambiri Zachitetezo:

Kuwunika kwachitetezo kwa Boc-D-His(Tos)-OH kuli ndi malire, koma ngati mankhwala, malingaliro otsatirawa otetezedwa ayenera kudziwidwa:

1. Pewani kupuma, kukhudzana ndi khungu ndi maso. Valani zida zodzitetezera zoyenera, monga magolovesi ndi magalasi.

2. Njira zabwino zama labotale ziyenera kutsatiridwa pakagwiritsidwe ntchito ndipo mpweya wabwino uyenera kutsimikizika.

3. Sungani mu chidebe chosindikizidwa, kutali ndi moto ndi okosijeni.

4. Tsatirani malamulo oyenerera ndi malangizo pakukonzekera.

Mukamagwiritsa ntchito Boc-D-His(Tos)-OH, chonde onetsetsani kuti mukutsatira malamulo okhudzana ndi chitetezo cha labotale ndi malangizo ogwiritsira ntchito, ndikusunga ndikusunga bwino mankhwala. Ngati ndi kotheka, tikulimbikitsidwa kugwira ntchito motsogozedwa ndi akatswiri.