N-Cbz-D-Tryptophan (CAS# 2279-15-4)

Mawu Oyamba

N(^ a)-Benzyloxycarbonyl-D-tryptophan(N(^ a)-Benzyloxycarbonyl-D-tryptophan) ndi mankhwala, omwe amadziwikanso kuti CBZ-D-Trp. Zotsatirazi ndizofotokozera za chikhalidwe chake, kagwiritsidwe ntchito, kapangidwe ndi chitetezo:

Chilengedwe:

N(^ a) -Benzyloxycarbonyl-D-tryptophan ndi yoyera mpaka chikasu cha kristalo cholimba. Ndiwokhazikika kutentha kwa firiji ndipo imatha kusungidwa kwa nthawi yayitali pansi pamikhalidwe yopanda madzi. Sisungunuke m'madzi, koma sungunuka mu zosungunulira zina monga methanol ndi dimethyl sulfoxide.

Gwiritsani ntchito:

N(^ a) -Benzyloxycarbonyl-D-tryptophan nthawi zambiri amagwiritsidwa ntchito ngati magulu oteteza mu kaphatikizidwe ka organic, makamaka mu kaphatikizidwe kakemikolo ka peptide. Ntchito yake yayikulu ndi yochokera ku ma amino acid pakuphatikizika kwa ma module apadera mu polypeptide kapena unyolo wa mapuloteni. Zitha kukhala ndi gawo lofunikira pakuphatikiza kwa mankhwala atsopano mwanjira iyi.

Njira:

Kukonzekera kwa N (^ a) -Benzyloxycarbonyl-D-tryptophan kawirikawiri kumachitika ndi kaphatikizidwe ka mankhwala. Choyamba, benzyl mowa ndi carbon dioxide anachita kupanga benzyloxycarboxylic asidi, ndiyeno amino asidi tryptophan ndi asidi benzyloxycarboxylic ndi esterified kupeza CBZ-D-Trp mankhwala. Zimene zimafunika kuthandizidwa ndi organic catalysts ndi solvents.

Zambiri Zachitetezo:

N(^ a) -Benzyloxycarbonyl-D-tryptophan ili ndi chidziwitso chochepa cha chitetezo, koma malinga ndi zomwe zilipo, nthawi zambiri imatengedwa ngati poizoni. Kuwonekera kwa nthawi yayitali kapena kuwonetseredwa mopitirira muyeso kungakhale ndi zotsatira zoipa pa thanzi. Choncho, njira zoyenera zotetezera ziyenera kuchitidwa pogwiritsa ntchito, kusunga ndi kusamalira chigawochi, kuphatikizapo kuvala zida zoyenera zodzitetezera ndikuyendetsa malo abwino kwambiri. Nthawi yomweyo, ndikofunikira kutsatira njira zoyenera zogwirira ntchito zachitetezo ndi njira zotayira.

Chonde dziwani kuti nkhaniyi ndi chidule chabe cha gulu lomwe likufunsidwa, ndipo kuwunika kwachiwopsezo ndi kuwunika kumayenera kuchitidwa pamalo enaake a labotale. Musanagwiritse ntchito mankhwala aliwonse, chonde onetsetsani kuti mwaphunzira zambiri zoyenera ndikufunsani katswiri pasadakhale.