N-Cbz-L-Leucine (CAS# 2018-66-8)
Ngozi ndi Chitetezo
| Zizindikiro Zowopsa | Xn - Zowopsa |
| Zizindikiro Zowopsa | R10 - Yoyaka R20/22 - Zowopsa pokoka mpweya komanso ngati zitamezedwa. R37/38 - Zokwiyitsa dongosolo la kupuma ndi khungu. R40 - Umboni wochepa wa zotsatira za carcinogenic R41 - Kuopsa kwa kuwonongeka kwakukulu kwa maso R36/37/38 - Zokwiyitsa maso, kupuma komanso khungu. R20/21/22 - Zowopsa pokoka mpweya, kukhudzana ndi khungu komanso kumeza. R67 - Nthunzi imatha kuyambitsa kugona komanso chizungulire R63 - Chiwopsezo chotheka kuvulaza mwana wosabadwa R19 - Itha kupanga ma peroxides ophulika |
| Kufotokozera Zachitetezo | S16 - Khalani kutali ndi magwero oyatsira. S26 - Mukakhudza maso, yambani nthawi yomweyo ndi madzi ambiri ndikupempha uphungu wachipatala. S36/37/39 - Valani zovala zodzitchinjiriza zoyenera, magolovesi ndi chitetezo chamaso / kumaso. S45 - Pakachitika ngozi kapena ngati simukumva bwino, funsani upangiri wachipatala nthawi yomweyo (onetsani chizindikirocho ngati kuli kotheka.) S36 - Valani zovala zoyenera zodzitetezera. S36/37 - Valani zovala zoyenera zodzitchinjiriza ndi magolovesi. S60 - Zinthuzi ndi chidebe chake ziyenera kutayidwa ngati zinyalala zowopsa. |
| Ma ID a UN | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| Mtengo wa RTECS | OH2921000 |
| HS kodi | 29242990 |
N-Cbz-L-Leucine (CAS # 2018-66-8) chiyambi
Cbz-L-leucine, dzina lonse la Boc-L-leucine (Boc imayimira gulu loteteza dibutoxycarbonyl), ndilochokera ku amino acid. Zotsatirazi ndizofotokozera za chikhalidwe chake, kugwiritsa ntchito, njira zopangira ndi chitetezo:
Ubwino:
- Maonekedwe: Makristalo oyera olimba
- Zosungunuka: Zosungunuka mu ethanol, dimethylformamide (DMF) ndi dichloromethane
Gwiritsani ntchito:
- CBZ-L-Leucine ndi ambiri ntchito amino acid kuteteza gulu kuti amateteza hydroxyl gulu la leucine pa synthesis wa peptides kuteteza kuti asachite ndi reactants ena. Mu kaphatikizidwe ka peptide komwe zotsalira zingapo za leucine ziyenera kuyambitsidwa, Cbz-L-leucine ingagwiritsidwe ntchito kuteteza gulu la hydroxyl la leucine pazotsatira zoyambira.
- Leucine ndi amino acid yofunikira yomwe imagwira ntchito yofunika kwambiri pakupanga mapuloteni ndi ntchito.
Njira:
- Kukonzekera kwa Cbz-L-leucine nthawi zambiri kumapezeka ndi momwe leucine imachitira ndi Boc-OSu (Boc—N-nitrocarbonyl-L-leucine). Pochita izi, Boc-OSu amakhala ngati woyambitsa gulu loteteza ndipo amakumana ndi esterification reaction ndi leucine kuti apange Cbz-L-leucine.
Zambiri Zachitetezo:
- Cbz-L-leucine ndi mankhwala ndipo ayenera kusungidwa bwino kutali ndi kuyatsa ndi okosijeni.
- Mukamagwiritsa ntchito, pewani kutulutsa fumbi lake kapena kukhudza khungu ndi maso.
- Tsatirani njira zodzitetezera pogwira ndi kusunga, ndipo valani zida zodzitetezera zoyenera monga magolovesi a labu ndi zoteteza maso.
