NN-Bis 9-fluorenylmethyloxycarbonyl-L-histidine CAS 98929-98-7

Kufotokozera Zachitetezo	S22 - Osapumira fumbi. S24/25 - Pewani kukhudzana ndi khungu ndi maso.
HS kodi	29242990

N(alpha),N(im)-di-fmoc-L-histidine(N(alpha),N(im)-di-fmoc-L-histidine) ndi mankhwala omwe amapangidwa ndi 9-fluorenecinol ndi L. - histidine. Mapangidwe ake a mankhwala ndi C42H38N4O8 ndipo molekyulu yake ndi 722.78g/mol.N(alpha),N(im)-di-fmoc-L-histidine ndi mankhwala omwe amateteza ma amino acid ndipo amagwiritsidwa ntchito kwambiri popanga organic synthesis ndi biochemical reactions. . Amagwiritsidwa ntchito makamaka kuwongolera kapangidwe ka mapuloteni ndi magwiridwe antchito, komanso kukulitsa ndikusintha maunyolo a polypeptide. Pawiri izi chimagwiritsidwa ntchito olimba gawo kaphatikizidwe njira zosinthira N-terminus ndi histidine zotsalira peptide ndi mapuloteni mamolekyu.

Njira yokonzekera N(alpha),N(im)-di-fmoc-L-histidine nthawi zambiri imakhala ndi masitepe atatu. Choyamba, ethylene glycol dimethyl ether ndi diazotoluene anachita pansi pa catalysis ya cuprous chloride kupanga 9-fluorenmethanol. Kenako, 9-fluorenecinol ndi L-histidine amachitidwa pansi pa acidic kuti apeze N(alpha),N(im)-di-fmoc-L-histidine. Pomaliza, choyeracho chimapezedwa ndi ma crystallization ndi masitepe oyeretsa.

Ponena za chitetezo, N(alpha),N(im)-Palibe malipoti ambiri okhudzana ndi chitetezo cha di-fmoc-L-histidine, kotero kusamala ndikofunikira. Akagwiritsidwa ntchito mu labotale, njira zotetezera ziyenera kuchitidwa, kuphatikizapo kuvala zida zodzitetezera zoyenera, monga magolovesi a labotale ndi magalasi, komanso kupewa kukhudzana ndi khungu ndi maso. Panthawi imodzimodziyo, ziyenera kusungidwa mu chidebe chouma, chodutsa mpweya komanso chotsekedwa, kutali ndi moto ndi zipangizo zoyaka. Kuti mudziwe zambiri zachitetezo, tikulimbikitsidwa kuti mufufuze zolemba zoyenera kapena kufunsa katswiri.