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Nicorandil (CAS# 65141-46-0) Chithunzi Chowonetsedwa
  • Nicorandil (CAS# 65141-46-0) 1

Nikorandil (CAS# 65141-46-0)

Chemical Property:

Molecular Formula C8H9N3O4
Misa ya Molar 211.17
Kuchulukana 1.4271 (kuyerekeza movutikira)
Melting Point 92 ° C
Boling Point 350.85 ° C (kuyerekeza molakwika)
Pophulikira 230 ° C
Kusungunuka DMSO:> 10 mg/mL. Amasungunuka mu methanol, ethanol, acetone kapena glacial acetic acid, amasungunuka pang'ono mu chloroform kapena m'madzi, pafupifupi osasungunuka mu ether kapena benzene.
Kuthamanga kwa Vapor 1.58E-08mmHg pa 25°C
Maonekedwe ufa woyera mpaka woyera ngati crystalline ufa
Mtundu zoyera mpaka zoyera
Merck 14,6521
Mkhalidwe Wosungira 2-8 ° C
Refractive Index 1.7400 (chiyerekezo)
MDL Mtengo wa MFCD00186520
Zakuthupi ndi Zamankhwala White crystalline ufa, wopanda fungo kapena wonunkhira pang'ono, owawa. Amasungunuka mu methanol, ethanol, acetone kapena acetic acid, osungunuka pang'ono mu chloroform kapena m'madzi, ochepa samasungunuka mu ether kapena benzene. Malo osungunuka 88.5-93.5 °c. Pachimake kawopsedwe LD50 makoswe (mg/kg): 1200-1300 pakamwa, 800-1000 mtsempha wa magazi.
Gwiritsani ntchito Pofuna kupewa matenda a mtima, angina pectoris
Maphunziro a in vitro Nicorandil (100 mM) inachulukitsa flavoprotein oxidation, koma sizinakhudze nembanemba panopa, kubwezeretsa mitoK(ATP) ndi pamwambaK (ATP) njira pa ndende pamwamba kuposa 10-fold. Nicorandil amachepetsa kufa kwa maselo mumtundu wa ischemic granulation, mphamvu ya mtima yomwe imatsekedwa ndi mitoK(ATP) blocker 5-hydroxydecanoic acid koma osati ndi surfaceK(ATP). Zotsatira za blocker channel HMR1098. Nicorandil (100 mM) imalepheretsa kutayika kwa TUNEL positivity, translocation ya cytochrome C, caspase-3 activation, ndi mitochondrial membrane potential (Delta(Psi)(m)). Kuwunika kwa ma cell odetsedwa ndi fluorescence Delta(Psi)(m) -indicator, tetramethylrhodamine ethyl ester (TMRE) ndi fluorescence activated cell sorter anasonyeza kuti, nicorandil imalepheretsa Delta(Psi)(m) depolarization m'njira yodalira ndende (EC(50) pafupifupi 40 mM, machulukitsidwe 100 mM). M'maselo onse opatsirana, Nicolandil adayambitsa njira yowongoka yofooka yamkati, glibenclamide-sensitive 80 pS K. M'maselo a HEK293T, Nicorandil amakonda kuyambitsa njira ya K(ATP) yomwe ili ndi SUR2B. Nicorandil (100 mM) inaletsa kwambiri chiwerengero cha maselo mu TUNEL-positive nuclei ndikuwonjezera 20 mM h2o2-induced caspase-3 ntchito. Kukhazikika kwa Nicorandil kumalepheretsa kutayika kwa DeltaPsim chifukwa cha H2O2.
Kuphunzira mu vivo Nicorandil (2.5 mg / kg tsiku ndi tsiku, po) pamodzi ndi Amlodipine (5.0 mg / kg tsiku lililonse, po) masiku atatu ochitapo kanthu amalepheretsa kwambiri kusintha ndi kubwezeretsa ntchito ya enzyme ku miyeso yomwe ili pafupi ndi makoswe abwino.

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Zizindikiro Zowopsa Xn - Zowopsa
Zizindikiro Zowopsa R22 - Zowopsa ngati zitamezedwa
R41 - Kuopsa kwa kuwonongeka kwakukulu kwa maso
Kufotokozera Zachitetezo S26 - Mukakhudza maso, yambani nthawi yomweyo ndi madzi ambiri ndikupempha uphungu wachipatala.
S39 - Valani chitetezo chamaso / kumaso.
WGK Germany 3
Mtengo wa RTECS US4667600
HS kodi 29333990
Poizoni LD50 mu makoswe (mg / kg): 1200-1300 pakamwa; 800-1000 iv (Nagano)

 

Mawu Oyamba

Nicolandil, yemwenso amadziwika kuti nicorandil amine, ndi organic pawiri. Zotsatirazi ndizofotokozera za katundu, ntchito, kukonzekera ndi chitetezo cha nicorandil:

 

Ubwino:

- Nicorandil ndi kristalo wopanda mtundu wolimba womwe umasungunuka m'madzi ndi zosungunulira organic.

- Ndi mankhwala amchere omwe amatha kuchitapo kanthu ndi zidulo kuti apange mchere wambiri.

- Nicorandil imakhala yokhazikika mumlengalenga, koma imatha kuwola ikakumana ndi kutentha kwambiri.

 

Gwiritsani ntchito:

- Nicolandil itha kugwiritsidwanso ntchito popanga organic synthesis catalysts, photosensitizers, etc.

 

Njira:

- Nicolandil nthawi zambiri amakonzedwa ndi zomwe dimethylamine ndi 2-carbonyl mankhwala.

- Zomwe zimachitika pansi pa zinthu za alkaline ndipo kutenthetsa kumachitika muzosungunulira zoyenera.

 

Zambiri Zachitetezo:

- Nicorandil ndiyotetezeka kwa anthu nthawi zambiri.

- Komabe, chisamaliro chiyenera kutengedwa kuti musakhudze maso, khungu, ndi kupuma.

- Valani zida zoyenera zodzitetezera (PPE) monga magalasi otetezera chitetezo, magolovesi ndi zida zopumira.

- Mukamagwiritsa ntchito kapena kusunga nicorandil, muyenera kusamala kuti musayatse komanso kutentha kwambiri.

 

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