Sodium nitroprusside dihydrate (CAS# 13755-38-9)

Chemical Property:

Molecular Formula	C5H4FeN6Na2O3
Molar Misa	297.95
Kuchulukana	1.72
Kusungunuka kwamadzi	Zosungunuka m'madzi. Mowa wosungunuka pang'ono.
Kusungunuka	Kusungunuka m'madzi (400 g/l) pa 20 °C, ndi ethanol (yosungunuka pang'ono).
Maonekedwe	Krustalo wofiira kwambiri
Specific Gravity	1.72
Mtundu	Ruby wofiira
Malire Owonetsera	ACGIH: TWA 1 mg/m3NIOSH: IDLH 25 mg/m3; TWA 1 mg/m3
Merck	14,8649
PH	5 (50g/l, H2O, 20 ℃)
Mkhalidwe Wosungira	2-8 ° C
Zomverera	Hygroscopic
MDL	Mtengo wa MFCD00149192
Zakuthupi ndi Zamankhwala	ufa wakristalo wofiirira, wopanda fungo; Zosakoma.
Gwiritsani ntchito	Amagwiritsidwa ntchito ngati reagent kuti adziwe aldehydes, acetone, sulfure dioxide, zinki, zitsulo zamchere, sulfide, etc.
Maphunziro a in vitro	Sodium nitroprusside ndi vasodilator yothandiza. Sodium nitroprusside imakhala ndi vasodilatory kwenikweni mu arterioles ndi ma venules. Nitroprusside ya sodium imaphwanya m'magazi kuti itulutse nitric oxide (NO). NO imayambitsa guanylate cyclase mu minofu yosalala ya mitsempha ndikuwonjezera kupanga kwa cGMP kwa intracellular. Izi pamapeto pake zimabweretsa kumasuka kwa minofu yosalala ya mitsempha, yomwe imakulitsa mitsempha yamagazi. Sodium nitroprusside amachepetsa kuchuluka kwa mtima yosalala minofu.
Kuphunzira mu vivo	Sodium nitroprusside (5 mg / kg) monga wopereka nitric oxide amachepetsa kwambiri matumbo a ischemia-reperfusion kuvulaza makoswe.

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Ngozi ndi Chitetezo

Zizindikiro Zowopsa	R25 - Poizoni ngati atamezedwa R26/27/28 – Poizoni kwambiri pokoka mpweya, kukhudzana ndi khungu komanso kummeza.
Kufotokozera Zachitetezo	S45 - Pakachitika ngozi kapena ngati simukumva bwino, funsani upangiri wachipatala nthawi yomweyo (onetsani chizindikirocho ngati kuli kotheka.) S36/37/39 - Valani zovala zodzitchinjiriza zoyenera, magolovesi ndi chitetezo chamaso / kumaso. S22 - Osapumira fumbi.
Ma ID a UN	UN 3288 6.1/PG 3
WGK Germany	3
Mtengo wa RTECS	LJ8925000
FLUKA BRAND F CODES	3
TSCA	Inde
HS kodi	28372000
Kalasi Yowopsa	6.1
Packing Group	III
Poizoni	LD50 pakamwa pa Kalulu: 99 mg/kg

13755-38-9

Buku

Onetsani zambiri

1. Tian, Ya-qin, et al. "Kuyerekeza njira zosiyanasiyana zochotsera ndikukhathamiritsa kwa chowonjezera chothandizidwa ndi microwave ...

13755-38-9 - Chiyambi

Kusungunuka m'madzi, kusungunuka pang'ono mu mowa. Njira yake yamadzimadzi ndi yosakhazikika ndipo imatha kuwola pang'onopang'ono ndikusanduka wobiriwira.

13755-38-9 - Zambiri Zothandizira

mawu oyamba	sodium nitroprusside (molecular formula: Na2[Fe(CN)5NO]· 2H2O, dzina la mankhwala: sodium nitroferricyanide dihydrate) ndi vasodilator yofulumira komanso yochepa, yomwe imagwiritsidwa ntchito pochiza matenda oopsa oopsa monga hypertensive crisis, hypertensive encephalopathy, malignant hypertension, paroxysmal hypertension isanayambe kapena itatha opaleshoni ya pheochromocytoma, ndi zina zotero, zitha kugwiritsidwanso ntchito kuwongolera hypotension panthawi ya opaleshoni.
zotsatira	sodium nitroprusside ndi vasodilator yamphamvu yogwira ntchito mwachangu, yomwe imakulitsa mwachindunji pamitsempha yosalala komanso yosalala ya venous, ndipo imachepetsa kukana kwa mitsempha yotumphukira mwa kukulitsa mitsempha yamagazi., Kupanga antihypertensive kwenikweni. Kuthamanga kwa mitsempha kungathenso kuchepetsa katunduyo musanayambe komanso pambuyo pa mtima, kupititsa patsogolo kutulutsa kwa mtima, ndi kuchepetsa kuchepa kwa magazi pamene valavu sitsekedwa, kotero kuti zizindikiro za kulephera kwa mtima zithetsedwe.
zizindikiro	1. imagwiritsidwa ntchito pazovuta zadzidzidzi zadzidzidzi zadzidzidzi, monga matenda oopsa kwambiri, matenda oopsa kwambiri, matenda oopsa kwambiri, matenda oopsa a paroxysmal hypertension isanayambe kapena itatha opaleshoni ya pheochromocytoma, ndipo ingagwiritsidwenso ntchito pofuna kuchepetsa kuthamanga kwa magazi panthawi ya opaleshoni ya opaleshoni. 2. Pachimake mtima kulephera, kuphatikizapo pachimake pulmonary edema. Amagwiritsidwanso ntchito pakulephera kwa mtima pachimake mu infarction ya myocardial kapena pamene valavu (mitral kapena aortic valve) sinatseke.
mankhwala a pharmacokinetics	kufika pachimake ndende magazi mwamsanga pambuyo mtsempha kukapanda kuleka, ndipo mlingo wake zimadalira mlingo. Izi zimapukusidwa ndi maselo ofiira a magazi mu cyanide, cyanide mu chiwindi ndi zimapukusidwa mu thiocyanate, ndi metabolite alibe vasodilating ntchito; cyanide amathanso kutenga nawo gawo mu metabolism ya vitamini B12. Izi zimagwira ntchito nthawi yomweyo pambuyo pa kuwongolera ndikufikira pachimake, ndikukhazikika kwa mphindi 1-10 mutasiya kudontha kwa mtsempha. Theka la moyo wa odwala omwe ali ndi vuto laimpso ndi masiku 7 (oyezedwa ndi thiocyanate), amatalika ngati aimpso sagwira bwino ntchito kapena sodium m'magazi ndi otsika kwambiri, ndipo amachotsedwa ndi impso.
Njira yopangira kukonzekera	sodium nitroprusside, kuphatikizapo masitepe otsatirawa: 1) Synthesizing mkuwa nitroso ferrocyanide: kuwonjezera mlingo woyenera wa madzi oyeretsedwa kupasuka potaziyamu nitroso-ferricyanide mu thanki crystallization, kutentha kwa 70-80 ℃ kupasuka kwathunthu, ndi pang'onopang'ono kuwonjezera mkuwa sulfate pentahydrate. amadzimadzi yankho dropwise, pambuyo zomwe zimatenthedwa kwa mphindi 30, centrifuge, keke centrifuged fyuluta (mkuwa nitroso ferricyanide) anaikidwa mu thanki crystallization. 2) Synthetic sodium nitroprusside (sodium nitronitroferricyanide): Konzani zodzaza ndi sodium bicarbonate amadzimadzi njira molingana ndi chakudya chiŵerengero, ndipo pang'onopang'ono kuponyera mu nitroso ferricyanide pa 30-60 madigiri C. Pambuyo anachita, centrifuge, sonkhanitsani filtrate ndi mafuta odzola. 3) Kuyikira ndi crystallization: Zosefera zosonkhanitsidwa ndi mafuta odzola amaponyedwa mu thanki ya vacuum, ndipo glacial acetic acid imawonjezedwa pang'onopang'ono mpaka palibe thovu lomwe limapangidwa. Yatsani pampu vakuyumu ndi kutentha kwa madigiri 40-60 C, kuyamba ndende, kuganizira ambiri makhiristo mpweya, kutseka nthunzi valavu, vakuyumu valavu kukonzekera crystallization. 4) Kuyanika kwa Centrifugal: pambuyo pa crystallization, supernatant imachotsedwa, makhiristo amagwedezeka mofanana ndi centrifuged, keke ya fyuluta imayikidwa mu mbale yachitsulo chosapanga dzimbiri, ndipo mankhwalawa amapezedwa ndi kuyanika.
ntchito zamoyo	Sodium Nitroprusside ndi vasodilator yamphamvu yomwe imagwira ntchito mwa kutulutsa NO m'magazi.
Zolinga	Mtengo
Gwiritsani ntchito	Amagwiritsidwa ntchito ngati reagent kutsimikiza kwa aldehydes, ketoni, sulfides, zinki, sulfure dioxide, etc. Amagwiritsidwa ntchito ngati reagent kutsimikiza kwa aldehydes, acetone, sulfure dioxide, zinki, zitsulo zamchere, sulfides, etc. Vasodilators. Kutsimikizira kwa aldehydes ndi ketoni, zinki, sulfure dioxide ndi alkali zitsulo sulfides. Kusanthula kwa Chromatic, kuyesa kwa mkodzo.