tert-butyl 2 4-dioxopiperidine-1-carboxylate (CAS# 845267-78-9)

Molecular Formula	C10H15NO4
Misa ya Molar	213.23
Kuchulukana	1.199
Boling Point	373.8±35.0 °C(Zonenedweratu)
Pophulikira	179.9°C
Kuthamanga kwa Vapor	8.72E-06mmHg pa 25°C
pKa	10.67±0.20 (Zonenedweratu)
Mkhalidwe Wosungira	Sungani pamalo amdima, Osindikizidwa owuma, Kutentha kwachipinda
Refractive Index	1.493
MDL	Mtengo wa MFCD10566071

Tsatanetsatane wa Zamalonda

Zizindikiro Zowopsa	20/21/22 - Zowopsa pokoka mpweya, kukhudzana ndi khungu komanso kumeza.
Kufotokozera Zachitetezo	S23 - Osapuma mpweya. S24/25 - Pewani kukhudzana ndi khungu ndi maso.
WGK Germany	3
HS kodi	29337900

Gwiritsani ntchito	2, 4-dipiperidon-1-formate tert-butyl formate ndi kaphatikizidwe ka phenoxymethyl-dihydrothiazolopyridone zotumphukira Zochita mu mankhwala, monga selective positive structure modulator (PAM) ya metabolized glutamate 5 (mGlu5) receptor.
ntchito	2, 4-dioperidone-1-tert-butyl formate imagwiritsidwa ntchito makamaka ngati organic wapakatikati ndi mankhwala wapakatikati, ndipo angagwiritsidwe ntchito mu labotale kafukufuku ndi chitukuko ndondomeko ndi mankhwala mankhwala ndondomeko kaphatikizidwe.
kukonzekera	sitepe a: onjezani EDCI(191.7g) ku DMF(400mL) njira ya 3-(tert-butoxycarbonylamino) propionic acid (189.2g,1.0mol), asidi meldamic (144.1g,1.0mol) ndi DMAP (135.0g,1.1mol) ) utakhazikika ndi kusamba kwa ayezi, 1.0mol). The chifukwa reactants anagwedezeka usiku kutentha firiji. Zotsatirazo zidazimitsidwa ndi 200mL H2O. The chifukwa osakaniza anawonjezera dropwise kuti H2O (2.0L) pansi makina yogwira mtima. Cholimba chomwe chinapezedwa chinasefedwa ndikutsukidwa bwino ndi madzi mpaka pH 7 kuti mupeze mankhwala (283g,90% zokolola). Khwerero B: Njira yothetsera 3-(2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-yl)-3-oxopropylcarbamate tert-butyl ester (100g,317.46mmol) mu toluene (1500mL) imatenthedwa pa 100 ° C kwa maola 4. The reactants ndi utakhazikika kutentha firiji ndipo amaunjikana pansi pa kupsyinjika kuchepetsedwa kuti apeze mankhwala osakhwima. The mankhwala (56g, 83% zokolola) anayeretsedwa ndi MTBE-akupera.