Z-DL-ALA-OH (CAS# 4132-86-9)

Mawu Oyamba

N-Carbobenzyloxy-DL-alanine ndi organic pawiri, kawirikawiri amafupikitsidwa monga Cbz-DL-Ala. Zotsatirazi ndizofotokozera za chikhalidwe chake, kagwiritsidwe ntchito, kapangidwe ndi chitetezo:

Chilengedwe:

N-Carbobenzyloxy-DL-alanine ndi crystalline yoyera yolimba yokhala ndi mamolekyulu a C12H13NO4 ndi molekyulu ya 235.24. Ili ndi malo awiri opangira chiral ndipo chifukwa chake imawonetsa ma isomers owoneka. Itha kusungunuka muzinthu zambiri zosungunulira organic, monga mowa ndi dimethylformamide. Ndi chinthu chokhazikika komanso chovuta kuti chiwole.

Gwiritsani ntchito:

N-Carbobenzyloxy-DL-alanine ndizomwe zimagwiritsidwa ntchito poteteza amino acid. Itha kugwiritsidwa ntchito popanga ma peptides ndi mapuloteni momwe magulu ake a carboxyl ndi amine amatha kulumikizidwa ndikusintha kwa ma condensation pakati pa ma amino acid kuti apange unyolo wa peptide. Gulu loteteza la N-benzyloxycarbonyl limatha kuchotsedwa ndi mikhalidwe yoyenera mukamaliza kuchitapo kanthu kuti abwezeretse kapangidwe ka amino acid koyambirira.

Njira Yokonzekera:

Kukonzekera kwa N-Carbobenzyloxy-DL-alanine nthawi zambiri kumachitika pogwiritsa ntchito N-benzyloxycarbonyl-alanine ndi kuchuluka koyenera kwa DCC (diisopropylcarbamate) mu zosungunulira zoyenera. Zomwe zimawononga madzi kuti zipange mawonekedwe a amide, omwe amayeretsedwa ndi crystallization kuti apereke zomwe mukufuna.

Zambiri Zachitetezo:

N-Carbobenzyloxy-DL-alanine nthawi zambiri imakhala yotetezeka ikagwiritsidwa ntchito pamikhalidwe yoyenera. Komabe, popeza ndi mankhwala, malangizo achitetezo a labotale amafunikabe kutsatiridwa. Zitha kukwiyitsa maso ndi khungu, choncho valani zida zoyenera zodzitetezera monga magolovesi ndi magalasi mukamagwira ntchito. Kuphatikiza apo, ziyenera kusungidwa pamalo owuma, opanda mpweya wabwino, kutali ndi moto ndi zida zoyaka moto. Kuti mumve zambiri za kasamalidwe ndi kasamalidwe kotetezedwa, onani tsamba loyenera lachitetezo (SDS) lamankhwala kapena funsani katswiri.